Localization of IgG1-producing cells within a hyperstimulated lymph node of mice infected with an intestinal nematode parasite

P. M. Knopf; C. B. Chapman; J. D. Hicks; T. E. Mandel; G. F. Mitchell

doi:10.1016/0165-2478(79)90016-6

Localization of IgG₁-producing cells within a hyperstimulated lymph node of mice infected with an intestinal nematode parasite

P. M. Knopf, C. B. Chapman, J. D. Hicks, T. E. Mandel, G. F. Mitchell

Research output: Contribution to journal › Article › Research › peer-review

3 Citations (Scopus)

Abstract

In the coeliac lymph node of IgG₁ hypergammaglobulinaemic BALB/c mice infected with the intestinal nematode, Nematospiroides dubius, the bulk of in vitro production of biosynthetically-labelled IgG₁ appeared to be concentrated in the cortical regions of the node and not the medulla. This was demonstrated by incubating segments of the grossly enlarged lymph node with [³H]leucine and assessing [³H]IgG₁ production by a protein A-Sepharose binding method.

Original language	English
Pages (from-to)	137-140
Number of pages	4
Journal	Immunology Letters
Volume	1
Issue number	3
DOIs	https://doi.org/10.1016/0165-2478(79)90016-6
Publication status	Published - Dec 1979
Externally published	Yes

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10.1016/0165-2478(79)90016-6

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title = "Localization of IgG1-producing cells within a hyperstimulated lymph node of mice infected with an intestinal nematode parasite",

abstract = "In the coeliac lymph node of IgG1 hypergammaglobulinaemic BALB/c mice infected with the intestinal nematode, Nematospiroides dubius, the bulk of in vitro production of biosynthetically-labelled IgG1 appeared to be concentrated in the cortical regions of the node and not the medulla. This was demonstrated by incubating segments of the grossly enlarged lymph node with [3H]leucine and assessing [3H]IgG1 production by a protein A-Sepharose binding method.",

author = "Knopf, {P. M.} and Chapman, {C. B.} and Hicks, {J. D.} and Mandel, {T. E.} and Mitchell, {G. F.}",

year = "1979",

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language = "English",

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T1 - Localization of IgG1-producing cells within a hyperstimulated lymph node of mice infected with an intestinal nematode parasite

AU - Knopf, P. M.

AU - Chapman, C. B.

AU - Hicks, J. D.

AU - Mandel, T. E.

AU - Mitchell, G. F.

PY - 1979/12

Y1 - 1979/12

N2 - In the coeliac lymph node of IgG1 hypergammaglobulinaemic BALB/c mice infected with the intestinal nematode, Nematospiroides dubius, the bulk of in vitro production of biosynthetically-labelled IgG1 appeared to be concentrated in the cortical regions of the node and not the medulla. This was demonstrated by incubating segments of the grossly enlarged lymph node with [3H]leucine and assessing [3H]IgG1 production by a protein A-Sepharose binding method.

AB - In the coeliac lymph node of IgG1 hypergammaglobulinaemic BALB/c mice infected with the intestinal nematode, Nematospiroides dubius, the bulk of in vitro production of biosynthetically-labelled IgG1 appeared to be concentrated in the cortical regions of the node and not the medulla. This was demonstrated by incubating segments of the grossly enlarged lymph node with [3H]leucine and assessing [3H]IgG1 production by a protein A-Sepharose binding method.

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DO - 10.1016/0165-2478(79)90016-6

M3 - Article

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SP - 137

EP - 140

JO - Immunology Letters

JF - Immunology Letters

IS - 3

ER -

Localization of IgG1-producing cells within a hyperstimulated lymph node of mice infected with an intestinal nematode parasite

Abstract

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Localization of IgG₁-producing cells within a hyperstimulated lymph node of mice infected with an intestinal nematode parasite