Localization of IgG1-producing cells within a hyperstimulated lymph node of mice infected with an intestinal nematode parasite

P. M. Knopf, C. B. Chapman, J. D. Hicks, T. E. Mandel, G. F. Mitchell

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In the coeliac lymph node of IgG1 hypergammaglobulinaemic BALB/c mice infected with the intestinal nematode, Nematospiroides dubius, the bulk of in vitro production of biosynthetically-labelled IgG1 appeared to be concentrated in the cortical regions of the node and not the medulla. This was demonstrated by incubating segments of the grossly enlarged lymph node with [3H]leucine and assessing [3H]IgG1 production by a protein A-Sepharose binding method.

Original languageEnglish
Pages (from-to)137-140
Number of pages4
JournalImmunology Letters
Issue number3
Publication statusPublished - Dec 1979
Externally publishedYes

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