Localization of β-adrenoceptors in the rabbit ear by light microscopic autoradiography

Heather G. Johnston, Roger J. Summers

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2 Citations (Scopus)

Abstract

The β-adrenoceptor antagonist [125I]cyanopindolol (CYP) was used to localize β-adrenoceptors in sections of rabbit ear. Biochemical studies demonstrated that the binding was stereoselective, and that the β-adrenoceptors are predominantly of the β2-subtype. Autoradiographic studies using 3H-Ultrofilm or nuclear emulsion coated coverslips showed high concentrations of β2-adrenoceptors present in the central ear artery, hyaline cartilage, nerve trunks, epithelium and sebaceous glands.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalEuropean Journal of Pharmacology
Volume115
Issue number1
DOIs
Publication statusPublished - 10 Sep 1985

Keywords

  • Autoradiography
  • Rabbit ear
  • [I]Cyanopindolol
  • β-Adrenoceptors

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