TY - JOUR
T1 - Local IL-17 production exerts a protective role in murine experimental glomerulonephritis
AU - Hamour, Sally
AU - Gan, Poh Yi
AU - Pepper, Ruth
AU - Florez-Barros, Fernanda
AU - Wang, Hsu-Han
AU - O'Sullivan, Kim
AU - Iwakura, Yoichiro
AU - Cook, Terence
AU - Pusey, Charles
AU - Holdsworth, Stephen Roger
AU - Salama, Alan
PY - 2015
Y1 - 2015
N2 - IL-17 is a pro-inflammatory cytokine implicated in the pathogenesis of glomerulonephritis and IL-17 deficient mice are protected from nephrotoxic nephritis. However, a regulatory role for IL-17 has recently emerged. We describe a novel protective function for IL-17 in the kidney. Bone marrow chimeras were created using wild-type and IL-17 deficient mice and nephrotoxic nephritis was induced. IL-17 deficient hosts transplanted with wild-type bone marrow had worse disease by all indices compared to wild-type to wild-type bone marrow transplants (serum urea p
AB - IL-17 is a pro-inflammatory cytokine implicated in the pathogenesis of glomerulonephritis and IL-17 deficient mice are protected from nephrotoxic nephritis. However, a regulatory role for IL-17 has recently emerged. We describe a novel protective function for IL-17 in the kidney. Bone marrow chimeras were created using wild-type and IL-17 deficient mice and nephrotoxic nephritis was induced. IL-17 deficient hosts transplanted with wild-type bone marrow had worse disease by all indices compared to wild-type to wild-type bone marrow transplants (serum urea p
UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552867/pdf/pone.0136238.pdf
U2 - 10.1371/journal.pone.0136238
DO - 10.1371/journal.pone.0136238
M3 - Article
SN - 1932-6203
VL - 10
JO - PLoS ONE
JF - PLoS ONE
IS - 8
M1 - e0136238
ER -