Local IL-17 production exerts a protective role in murine experimental glomerulonephritis

Sally Hamour, Poh Yi Gan, Ruth Pepper, Fernanda Florez-Barros, Hsu-Han Wang, Kim O'Sullivan, Yoichiro Iwakura, Terence Cook, Charles Pusey, Stephen Roger Holdsworth, Alan Salama

Research output: Contribution to journalArticleResearchpeer-review

Abstract

IL-17 is a pro-inflammatory cytokine implicated in the pathogenesis of glomerulonephritis and IL-17 deficient mice are protected from nephrotoxic nephritis. However, a regulatory role for IL-17 has recently emerged. We describe a novel protective function for IL-17 in the kidney. Bone marrow chimeras were created using wild-type and IL-17 deficient mice and nephrotoxic nephritis was induced. IL-17 deficient hosts transplanted with wild-type bone marrow had worse disease by all indices compared to wild-type to wild-type bone marrow transplants (serum urea p
Original languageEnglish
Article numbere0136238
Number of pages16
JournalPLoS ONE
Volume10
Issue number8
DOIs
Publication statusPublished - 2015

Cite this

Hamour, Sally ; Gan, Poh Yi ; Pepper, Ruth ; Florez-Barros, Fernanda ; Wang, Hsu-Han ; O'Sullivan, Kim ; Iwakura, Yoichiro ; Cook, Terence ; Pusey, Charles ; Holdsworth, Stephen Roger ; Salama, Alan. / Local IL-17 production exerts a protective role in murine experimental glomerulonephritis. In: PLoS ONE. 2015 ; Vol. 10, No. 8.
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abstract = "IL-17 is a pro-inflammatory cytokine implicated in the pathogenesis of glomerulonephritis and IL-17 deficient mice are protected from nephrotoxic nephritis. However, a regulatory role for IL-17 has recently emerged. We describe a novel protective function for IL-17 in the kidney. Bone marrow chimeras were created using wild-type and IL-17 deficient mice and nephrotoxic nephritis was induced. IL-17 deficient hosts transplanted with wild-type bone marrow had worse disease by all indices compared to wild-type to wild-type bone marrow transplants (serum urea p",
author = "Sally Hamour and Gan, {Poh Yi} and Ruth Pepper and Fernanda Florez-Barros and Hsu-Han Wang and Kim O'Sullivan and Yoichiro Iwakura and Terence Cook and Charles Pusey and Holdsworth, {Stephen Roger} and Alan Salama",
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Hamour, S, Gan, PY, Pepper, R, Florez-Barros, F, Wang, H-H, O'Sullivan, K, Iwakura, Y, Cook, T, Pusey, C, Holdsworth, SR & Salama, A 2015, 'Local IL-17 production exerts a protective role in murine experimental glomerulonephritis', PLoS ONE, vol. 10, no. 8, e0136238. https://doi.org/10.1371/journal.pone.0136238

Local IL-17 production exerts a protective role in murine experimental glomerulonephritis. / Hamour, Sally; Gan, Poh Yi; Pepper, Ruth; Florez-Barros, Fernanda; Wang, Hsu-Han; O'Sullivan, Kim; Iwakura, Yoichiro; Cook, Terence; Pusey, Charles; Holdsworth, Stephen Roger; Salama, Alan.

In: PLoS ONE, Vol. 10, No. 8, e0136238, 2015.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Local IL-17 production exerts a protective role in murine experimental glomerulonephritis

AU - Hamour, Sally

AU - Gan, Poh Yi

AU - Pepper, Ruth

AU - Florez-Barros, Fernanda

AU - Wang, Hsu-Han

AU - O'Sullivan, Kim

AU - Iwakura, Yoichiro

AU - Cook, Terence

AU - Pusey, Charles

AU - Holdsworth, Stephen Roger

AU - Salama, Alan

PY - 2015

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AB - IL-17 is a pro-inflammatory cytokine implicated in the pathogenesis of glomerulonephritis and IL-17 deficient mice are protected from nephrotoxic nephritis. However, a regulatory role for IL-17 has recently emerged. We describe a novel protective function for IL-17 in the kidney. Bone marrow chimeras were created using wild-type and IL-17 deficient mice and nephrotoxic nephritis was induced. IL-17 deficient hosts transplanted with wild-type bone marrow had worse disease by all indices compared to wild-type to wild-type bone marrow transplants (serum urea p

UR - http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4552867/pdf/pone.0136238.pdf

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