Local IL-17 production exerts a protective role in murine experimental glomerulonephritis

Sally Hamour, Poh Yi Gan, Ruth Pepper, Fernanda Florez-Barros, Hsu-Han Wang, Kim O'Sullivan, Yoichiro Iwakura, Terence Cook, Charles Pusey, Stephen Roger Holdsworth, Alan Salama

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Abstract

IL-17 is a pro-inflammatory cytokine implicated in the pathogenesis of glomerulonephritis and IL-17 deficient mice are protected from nephrotoxic nephritis. However, a regulatory role for IL-17 has recently emerged. We describe a novel protective function for IL-17 in the kidney. Bone marrow chimeras were created using wild-type and IL-17 deficient mice and nephrotoxic nephritis was induced. IL-17 deficient hosts transplanted with wild-type bone marrow had worse disease by all indices compared to wild-type to wild-type bone marrow transplants (serum urea p
Original languageEnglish
Article numbere0136238
Number of pages16
JournalPLoS ONE
Volume10
Issue number8
DOIs
Publication statusPublished - 2015

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