Local field potential phase modulates neural responses to intracortical electrical stimulation

Timothy John Allison-Walker; Maureen Ann Hagan; Nicholas Seow Chiang Price; Yan Tat Wong

doi:10.1109/EMBC44109.2020.9176186

Local field potential phase modulates neural responses to intracortical electrical stimulation

Timothy John Allison-Walker, Maureen Ann Hagan, Nicholas Seow Chiang Price, Yan Tat Wong

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

6 Citations (Scopus)

Abstract

Cortical visual prostheses could one day help restore sight to the blind by targeting the visual cortex with electrical stimulation. However, power consumption and limited spatial resolution impose limits on performance, while large amounts of electrical charge sometimes necessary to evoke phosphenes can cause seizures. Here, we propose the use of the local field potential as a control signal for the timing of stimulation to reduce charge requirements. In Sprague-Dawley rats, visual cortex was electrically stimulated at random times, and neural responses recorded. Electrical stimulation at specific phases of the local field potential required smaller amounts of charge to elicit spikes than naïve stimulation. Incorporating this into prosthesis design could improve their safety and efficacy.

Original language	English
Title of host publication	2020 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC)
Place of Publication	Piscataway NJ USA
Publisher	IEEE, Institute of Electrical and Electronics Engineers
Pages	3521-3524
Number of pages	4
ISBN (Electronic)	9781728119908
ISBN (Print)	9781728119915
DOIs	https://doi.org/10.1109/EMBC44109.2020.9176186
Publication status	Published - 2020
Event	International Conference of the IEEE Engineering in Medicine and Biology Society 2020 - Montreal, Canada Duration: 20 Jul 2020 → 24 Jul 2020 Conference number: 42nd https://embc.embs.org/2020/ https://ieeexplore.ieee.org/xpl/conhome/9167168/proceeding (Proceedings)

Publication series

Name	Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS
Publisher	IEEE, Institute of Electrical and Electronics Engineers
Volume	2020-July
ISSN (Print)	1557-170X
ISSN (Electronic)	2694-0604

Conference

Conference	International Conference of the IEEE Engineering in Medicine and Biology Society 2020
Abbreviated title	EMBC 2020
Country/Territory	Canada
City	Montreal
Period	20/07/20 → 24/07/20
Internet address	https://embc.embs.org/2020/ https://ieeexplore.ieee.org/xpl/conhome/9167168/proceeding (Proceedings)

Access to Document

10.1109/EMBC44109.2020.9176186

Cite this

Allison-Walker, T. J., Ann Hagan, M., Chiang Price, N. S., & Tat Wong, Y. (2020). Local field potential phase modulates neural responses to intracortical electrical stimulation. In 2020 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC) (pp. 3521-3524). (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2020-July). IEEE, Institute of Electrical and Electronics Engineers. https://doi.org/10.1109/EMBC44109.2020.9176186

Allison-Walker, Timothy John ; Ann Hagan, Maureen ; Chiang Price, Nicholas Seow et al. / Local field potential phase modulates neural responses to intracortical electrical stimulation. 2020 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC). Piscataway NJ USA : IEEE, Institute of Electrical and Electronics Engineers, 2020. pp. 3521-3524 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS).

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title = "Local field potential phase modulates neural responses to intracortical electrical stimulation",

abstract = "Cortical visual prostheses could one day help restore sight to the blind by targeting the visual cortex with electrical stimulation. However, power consumption and limited spatial resolution impose limits on performance, while large amounts of electrical charge sometimes necessary to evoke phosphenes can cause seizures. Here, we propose the use of the local field potential as a control signal for the timing of stimulation to reduce charge requirements. In Sprague-Dawley rats, visual cortex was electrically stimulated at random times, and neural responses recorded. Electrical stimulation at specific phases of the local field potential required smaller amounts of charge to elicit spikes than na{\"i}ve stimulation. Incorporating this into prosthesis design could improve their safety and efficacy.",

author = "Allison-Walker, {Timothy John} and {Ann Hagan}, Maureen and {Chiang Price}, {Nicholas Seow} and {Tat Wong}, Yan",

note = "Publisher Copyright: {\textcopyright} 2020 IEEE. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.; International Conference of the IEEE Engineering in Medicine and Biology Society 2020, EMBC 2020 ; Conference date: 20-07-2020 Through 24-07-2020",

year = "2020",

doi = "10.1109/EMBC44109.2020.9176186",

language = "English",

isbn = "9781728119915",

series = "Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS",

publisher = "IEEE, Institute of Electrical and Electronics Engineers",

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booktitle = "2020 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC)",

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Allison-Walker, TJ , Ann Hagan, M , Chiang Price, NS & Tat Wong, Y 2020, Local field potential phase modulates neural responses to intracortical electrical stimulation. in 2020 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC). Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, vol. 2020-July, IEEE, Institute of Electrical and Electronics Engineers, Piscataway NJ USA, pp. 3521-3524, International Conference of the IEEE Engineering in Medicine and Biology Society 2020, Montreal, Quebec, Canada, 20/07/20. https://doi.org/10.1109/EMBC44109.2020.9176186

Local field potential phase modulates neural responses to intracortical electrical stimulation. / Allison-Walker, Timothy John ; Ann Hagan, Maureen ; Chiang Price, Nicholas Seow et al.
2020 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC). Piscataway NJ USA: IEEE, Institute of Electrical and Electronics Engineers, 2020. p. 3521-3524 (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS; Vol. 2020-July).

Research output: Chapter in Book/Report/Conference proceeding › Conference Paper › Research › peer-review

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AB - Cortical visual prostheses could one day help restore sight to the blind by targeting the visual cortex with electrical stimulation. However, power consumption and limited spatial resolution impose limits on performance, while large amounts of electrical charge sometimes necessary to evoke phosphenes can cause seizures. Here, we propose the use of the local field potential as a control signal for the timing of stimulation to reduce charge requirements. In Sprague-Dawley rats, visual cortex was electrically stimulated at random times, and neural responses recorded. Electrical stimulation at specific phases of the local field potential required smaller amounts of charge to elicit spikes than naïve stimulation. Incorporating this into prosthesis design could improve their safety and efficacy.

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Allison-Walker TJ , Ann Hagan M , Chiang Price NS , Tat Wong Y. Local field potential phase modulates neural responses to intracortical electrical stimulation. In 2020 42nd Annual International Conferences of the IEEE Engineering in Medicine and Biology Society (EMBC). Piscataway NJ USA: IEEE, Institute of Electrical and Electronics Engineers. 2020. p. 3521-3524. (Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS). doi: 10.1109/EMBC44109.2020.9176186

Local field potential phase modulates neural responses to intracortical electrical stimulation

Abstract

Publication series

Conference

Access to Document

Other files and links

From synapses to networks: understanding how brain networks guide behaviour

Oscillations as a mechanism for neural communication

Integration of feedforward and feedback circuits for decision-making

Cite this

Local field potential phase modulates neural responses to intracortical electrical stimulation

Abstract

Publication series

Conference

Access to Document

Other files and links

Projects

From synapses to networks: understanding how brain networks guide behaviour

Oscillations as a mechanism for neural communication

Integration of feedforward and feedback circuits for decision-making

Cite this