Local Arrangement of Fibronectin by Myofibroblasts Governs Peripheral Nuclear Positioning in Muscle Cells

William Roman, João P. Martins, Edgar R. Gomes

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)


A hallmark of skeletal muscle cells is the position of nuclei at the cell periphery. Roman et al. show that myofibroblasts deposit extracellular components—fibronectin—at the surface of developing muscle cells to locally attract myonuclei to the cell periphery.

Original languageEnglish
Pages (from-to)102-111.e6
Number of pages17
JournalDevelopmental Cell
Issue number1
Publication statusPublished - 2 Jul 2018
Externally publishedYes


  • cell-cell interaction
  • extracellular matrix signaling
  • fibronectin
  • muscle development
  • nuclear movement
  • nuclear position

Cite this