LKB1 expression is inhibited by estradiol-17beta in MCF-7 cells

Kristy Brown, Kerry McInnes, Kiyoshi Takagi, Katsuhiko Ono, Nicole Hunger, Lin Wang, Hironobu Sasano, Evan Simpson

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23 Citations (Scopus)

Abstract

The liver kinase B1 (LKB1) is encoded by the STK11 gene and acts as a tumour suppressor and a regulator of energy homeostasis. LKB1 expression is reduced in primary breast tumours compared to normal breast epithelium. Although its expression in primary tumours does not appear to correlate with estrogen receptor (ER) status, it is differentially expressed in breast cancer cell lines where ER-negative cells have lower LKB1 expression than ER-positive cells. The present study aimed to examine the effects of estradiol on LKB1 expression and activity in the ER-positive breast cancer cell line MCF-7. Results demonstrate that estradiol causes a dose-dependent decrease in LKB1 transcript and protein expression and consistent with this, a significant decrease in the phosphorylation of the LKB1 target AMPK (P
Original languageEnglish
Pages (from-to)439 - 443
Number of pages5
JournalJournal of Steroid Biochemistry and Molecular Biology
Volume127
Issue number3-5
DOIs
Publication statusPublished - 2011

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