TY - JOUR
T1 - LKB1 expression is inhibited by estradiol-17beta in MCF-7 cells
AU - Brown, Kristy
AU - McInnes, Kerry
AU - Takagi, Kiyoshi
AU - Ono, Katsuhiko
AU - Hunger, Nicole
AU - Wang, Lin
AU - Sasano, Hironobu
AU - Simpson, Evan
PY - 2011
Y1 - 2011
N2 - The liver kinase B1 (LKB1) is encoded by the STK11 gene and acts as a tumour suppressor and a regulator of energy homeostasis. LKB1 expression is reduced in primary breast tumours compared to normal breast epithelium. Although its expression in primary tumours does not appear to correlate with estrogen receptor (ER) status, it is differentially expressed in breast cancer cell lines where ER-negative cells have lower LKB1 expression than ER-positive cells. The present study aimed to examine the effects of estradiol on LKB1 expression and activity in the ER-positive breast cancer cell line MCF-7. Results demonstrate that estradiol causes a dose-dependent decrease in LKB1 transcript and protein expression and consistent with this, a significant decrease in the phosphorylation of the LKB1 target AMPK (P
AB - The liver kinase B1 (LKB1) is encoded by the STK11 gene and acts as a tumour suppressor and a regulator of energy homeostasis. LKB1 expression is reduced in primary breast tumours compared to normal breast epithelium. Although its expression in primary tumours does not appear to correlate with estrogen receptor (ER) status, it is differentially expressed in breast cancer cell lines where ER-negative cells have lower LKB1 expression than ER-positive cells. The present study aimed to examine the effects of estradiol on LKB1 expression and activity in the ER-positive breast cancer cell line MCF-7. Results demonstrate that estradiol causes a dose-dependent decrease in LKB1 transcript and protein expression and consistent with this, a significant decrease in the phosphorylation of the LKB1 target AMPK (P
UR - http://www.ncbi.nlm.nih.gov/pubmed/21689749?dopt=Citation
U2 - 10.1016/j.jsbmb.2011.06.005
DO - 10.1016/j.jsbmb.2011.06.005
M3 - Article
SN - 0960-0760
VL - 127
SP - 439
EP - 443
JO - Journal of Steroid Biochemistry and Molecular Biology
JF - Journal of Steroid Biochemistry and Molecular Biology
IS - 3-5
ER -
