Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infection

Larisa Dubrovsky; Rachel Van Duyne; Svetlana Senina; Irene Guendel; Tatiana Pushkarsky; Dmitri Sviridov; Fatah Kashanchi; Michael Bukrinsky

doi:10.1016/j.bbrc.2012.01.137

Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infection

Larisa Dubrovsky, Rachel Van Duyne, Svetlana Senina, Irene Guendel, Tatiana Pushkarsky, Dmitri Sviridov, Fatah Kashanchi, Michael Bukrinsky

Research output: Contribution to journal › Article › Research › peer-review

19 Citations (Scopus)

Abstract

HIV-infected subjects are at high risk of developing atherosclerosis, in part due to virus-induced impairment of HDL metabolism. Here, using as a model of HIV infection the NOD.Cg-Prkdc ^scidIL2rg ^tm1Wjl/SzJ (NSG) mice humanized by human stem cell transplantation, we demonstrate that LXR agonist TO901317 potently reduces viral replication and prevents HIV-induced reduction of plasma HDL. These results establish that humanized mice can be used to investigate the mechanisms of HIV-induced impairment of HDL formation, a major feature of dyslipidemia associated with HIV-1 infection, and show potential benefits of developing LXR agonists for treatment of HIV-associated cardio-vascular disease.

Original language	English
Pages (from-to)	95-98
Number of pages	4
Journal	Biochemical and Biophysical Research Communications
Volume	419
Issue number	1
DOIs	https://doi.org/10.1016/j.bbrc.2012.01.137
Publication status	Published - 2 Mar 2012
Externally published	Yes

Keywords

Atherosclerosis
HIV-1
Humanized mice
Liver X receptor agonist
Pathogenesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.bbrc.2012.01.137

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Dubrovsky, L., Duyne, R. V., Senina, S., Guendel, I., Pushkarsky, T., Sviridov, D., Kashanchi, F., & Bukrinsky, M. (2012). Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infection. Biochemical and Biophysical Research Communications, 419(1), 95-98. https://doi.org/10.1016/j.bbrc.2012.01.137

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title = "Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infection",

abstract = "HIV-infected subjects are at high risk of developing atherosclerosis, in part due to virus-induced impairment of HDL metabolism. Here, using as a model of HIV infection the NOD.Cg-Prkdc scidIL2rg tm1Wjl/SzJ (NSG) mice humanized by human stem cell transplantation, we demonstrate that LXR agonist TO901317 potently reduces viral replication and prevents HIV-induced reduction of plasma HDL. These results establish that humanized mice can be used to investigate the mechanisms of HIV-induced impairment of HDL formation, a major feature of dyslipidemia associated with HIV-1 infection, and show potential benefits of developing LXR agonists for treatment of HIV-associated cardio-vascular disease.",

keywords = "Atherosclerosis, HIV-1, Humanized mice, Liver X receptor agonist, Pathogenesis",

author = "Larisa Dubrovsky and Duyne, {Rachel Van} and Svetlana Senina and Irene Guendel and Tatiana Pushkarsky and Dmitri Sviridov and Fatah Kashanchi and Michael Bukrinsky",

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Dubrovsky, L, Duyne, RV, Senina, S, Guendel, I, Pushkarsky, T, Sviridov, D, Kashanchi, F & Bukrinsky, M 2012, 'Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infection', Biochemical and Biophysical Research Communications, vol. 419, no. 1, pp. 95-98. https://doi.org/10.1016/j.bbrc.2012.01.137

Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infection. / Dubrovsky, Larisa; Duyne, Rachel Van; Senina, Svetlana et al.
In: Biochemical and Biophysical Research Communications, Vol. 419, No. 1, 02.03.2012, p. 95-98.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infection

AU - Dubrovsky, Larisa

AU - Duyne, Rachel Van

AU - Senina, Svetlana

AU - Guendel, Irene

AU - Pushkarsky, Tatiana

AU - Sviridov, Dmitri

AU - Kashanchi, Fatah

AU - Bukrinsky, Michael

PY - 2012/3/2

Y1 - 2012/3/2

N2 - HIV-infected subjects are at high risk of developing atherosclerosis, in part due to virus-induced impairment of HDL metabolism. Here, using as a model of HIV infection the NOD.Cg-Prkdc scidIL2rg tm1Wjl/SzJ (NSG) mice humanized by human stem cell transplantation, we demonstrate that LXR agonist TO901317 potently reduces viral replication and prevents HIV-induced reduction of plasma HDL. These results establish that humanized mice can be used to investigate the mechanisms of HIV-induced impairment of HDL formation, a major feature of dyslipidemia associated with HIV-1 infection, and show potential benefits of developing LXR agonists for treatment of HIV-associated cardio-vascular disease.

AB - HIV-infected subjects are at high risk of developing atherosclerosis, in part due to virus-induced impairment of HDL metabolism. Here, using as a model of HIV infection the NOD.Cg-Prkdc scidIL2rg tm1Wjl/SzJ (NSG) mice humanized by human stem cell transplantation, we demonstrate that LXR agonist TO901317 potently reduces viral replication and prevents HIV-induced reduction of plasma HDL. These results establish that humanized mice can be used to investigate the mechanisms of HIV-induced impairment of HDL formation, a major feature of dyslipidemia associated with HIV-1 infection, and show potential benefits of developing LXR agonists for treatment of HIV-associated cardio-vascular disease.

KW - Atherosclerosis

KW - HIV-1

KW - Humanized mice

KW - Liver X receptor agonist

KW - Pathogenesis

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M3 - Article

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SN - 0006-291X

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JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

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Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infection

Abstract

Keywords

UN SDGs

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