Liver X receptor agonist inhibits HIV-1 replication and prevents HIV-induced reduction of plasma HDL in humanized mouse model of HIV infection

Larisa Dubrovsky, Rachel Van Duyne, Svetlana Senina, Irene Guendel, Tatiana Pushkarsky, Dmitri Sviridov, Fatah Kashanchi, Michael Bukrinsky

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16 Citations (Scopus)

Abstract

HIV-infected subjects are at high risk of developing atherosclerosis, in part due to virus-induced impairment of HDL metabolism. Here, using as a model of HIV infection the NOD.Cg-Prkdc scidIL2rg tm1Wjl/SzJ (NSG) mice humanized by human stem cell transplantation, we demonstrate that LXR agonist TO901317 potently reduces viral replication and prevents HIV-induced reduction of plasma HDL. These results establish that humanized mice can be used to investigate the mechanisms of HIV-induced impairment of HDL formation, a major feature of dyslipidemia associated with HIV-1 infection, and show potential benefits of developing LXR agonists for treatment of HIV-associated cardio-vascular disease.

Original languageEnglish
Pages (from-to)95-98
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume419
Issue number1
DOIs
Publication statusPublished - 2 Mar 2012
Externally publishedYes

Keywords

  • Atherosclerosis
  • HIV-1
  • Humanized mice
  • Liver X receptor agonist
  • Pathogenesis

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