Liver transplantation rapidly stops cerebral ammonia uptake in fulminant hepatic failure

Neil J. Glassford, K. J. Farley, Stephen Warrillow, Rinaldo Bellomo

Research output: Contribution to journalArticleOtherpeer-review

1 Citation (Scopus)


This report describes the effect of liver transplantation on transcerebral ammonia uptake in a case of fulminant hepatic failure. A young woman with fulminant hepatic failure and coma received monitoring of transcerebral ammonia uptake before and after orthotopic liver transplantation. Before liver transplantation, median transcerebral ammonia uptake was 8 μmol/L. After liver transplantation, ammonia uptake decreased to 0 μmol/L. Fulminant hepatic failure is associated with transcerebral ammonia uptake, which is fully and rapidly corrected by liver transplantation.

Original languageEnglish
Pages (from-to)113-118
Number of pages6
JournalCritical Care and Resuscitation
Issue number2
Publication statusPublished - 1 Dec 2011
Externally publishedYes


  • Adult Ammonia/*metabolism Brain/*metabolism Female Follow-Up Studies Hepatic Encephalopathy/*etiology/metabolism/surgery Humans Liver Failure, Acute/complications/metabolism/*surgery Liver Transplantation/*methods

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