This report describes the effect of liver transplantation on transcerebral ammonia uptake in a case of fulminant hepatic failure. A young woman with fulminant hepatic failure and coma received monitoring of transcerebral ammonia uptake before and after orthotopic liver transplantation. Before liver transplantation, median transcerebral ammonia uptake was 8 μmol/L. After liver transplantation, ammonia uptake decreased to 0 μmol/L. Fulminant hepatic failure is associated with transcerebral ammonia uptake, which is fully and rapidly corrected by liver transplantation.
|Number of pages||6|
|Journal||Critical Care and Resuscitation|
|Publication status||Published - 1 Dec 2011|
- Adult Ammonia/*metabolism Brain/*metabolism Female Follow-Up Studies Hepatic Encephalopathy/*etiology/metabolism/surgery Humans Liver Failure, Acute/complications/metabolism/*surgery Liver Transplantation/*methods