Liver transplantation rapidly stops cerebral ammonia uptake in fulminant hepatic failure

Neil J. Glassford; K. J. Farley; Stephen Warrillow; Rinaldo Bellomo

Liver transplantation rapidly stops cerebral ammonia uptake in fulminant hepatic failure

Neil J. Glassford, K. J. Farley, Stephen Warrillow, Rinaldo Bellomo

Research output: Contribution to journal › Article › Other › peer-review

Abstract

This report describes the effect of liver transplantation on transcerebral ammonia uptake in a case of fulminant hepatic failure. A young woman with fulminant hepatic failure and coma received monitoring of transcerebral ammonia uptake before and after orthotopic liver transplantation. Before liver transplantation, median transcerebral ammonia uptake was 8 μmol/L. After liver transplantation, ammonia uptake decreased to 0 μmol/L. Fulminant hepatic failure is associated with transcerebral ammonia uptake, which is fully and rapidly corrected by liver transplantation.

Original language	English
Pages (from-to)	113-118
Number of pages	6
Journal	Critical Care and Resuscitation
Volume	13
Issue number	2
Publication status	Published - 1 Dec 2011
Externally published	Yes

Keywords

Adult Ammonia/*metabolism Brain/*metabolism Female Follow-Up Studies Hepatic Encephalopathy/*etiology/metabolism/surgery Humans Liver Failure, Acute/complications/metabolism/*surgery Liver Transplantation/*methods

Cite this

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title = "Liver transplantation rapidly stops cerebral ammonia uptake in fulminant hepatic failure",

abstract = "This report describes the effect of liver transplantation on transcerebral ammonia uptake in a case of fulminant hepatic failure. A young woman with fulminant hepatic failure and coma received monitoring of transcerebral ammonia uptake before and after orthotopic liver transplantation. Before liver transplantation, median transcerebral ammonia uptake was 8 μmol/L. After liver transplantation, ammonia uptake decreased to 0 μmol/L. Fulminant hepatic failure is associated with transcerebral ammonia uptake, which is fully and rapidly corrected by liver transplantation.",

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author = "Glassford, {Neil J.} and Farley, {K. J.} and Stephen Warrillow and Rinaldo Bellomo",

note = "Glassford, Neil J Farley, K J Warrillow, Stephen Bellomo, Rinaldo Case Reports Journal Article Australia Crit Care Resusc. 2011 Jun;13(2):113-8.",

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AU - Glassford, Neil J.

AU - Farley, K. J.

AU - Warrillow, Stephen

AU - Bellomo, Rinaldo

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N2 - This report describes the effect of liver transplantation on transcerebral ammonia uptake in a case of fulminant hepatic failure. A young woman with fulminant hepatic failure and coma received monitoring of transcerebral ammonia uptake before and after orthotopic liver transplantation. Before liver transplantation, median transcerebral ammonia uptake was 8 μmol/L. After liver transplantation, ammonia uptake decreased to 0 μmol/L. Fulminant hepatic failure is associated with transcerebral ammonia uptake, which is fully and rapidly corrected by liver transplantation.

AB - This report describes the effect of liver transplantation on transcerebral ammonia uptake in a case of fulminant hepatic failure. A young woman with fulminant hepatic failure and coma received monitoring of transcerebral ammonia uptake before and after orthotopic liver transplantation. Before liver transplantation, median transcerebral ammonia uptake was 8 μmol/L. After liver transplantation, ammonia uptake decreased to 0 μmol/L. Fulminant hepatic failure is associated with transcerebral ammonia uptake, which is fully and rapidly corrected by liver transplantation.

KW - Adult Ammonia/metabolism Brain/metabolism Female Follow-Up Studies Hepatic Encephalopathy/etiology/metabolism/surgery Humans Liver Failure, Acute/complications/metabolism/surgery Liver Transplantation/methods

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EP - 118

JO - Critical Care and Resuscitation

JF - Critical Care and Resuscitation

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ER -

Liver transplantation rapidly stops cerebral ammonia uptake in fulminant hepatic failure

Abstract

Keywords

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