Liver regeneration stimulates tumor metastases

Nadia Harun, Mehrdad Nikfarjam, Vijayaragavan Muralidharan, Christopher Christophi

Research output: Contribution to journalArticleResearchpeer-review

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Abstract

Background. Partial hepatectomy for patients with colorectal liver metastases is associated with a tumor recurrence rate approaching 80 post-resection. Different factors and phases associated with regeneration of the liver are implicated in tumor recurrence. This study investigates the effects of the early and late phases of liver regeneration and the impact of the degree of liver resection on stimulating tumor growth and metastasis. Materials and methods. Groups of mice underwent partial hepatectomy (37 or 70 ) and were then challenged with colorectal liver carcinoma (CRC) tumors immediately after liver resection (early and late phase effect) or 6 days post liver resection (late phase effect). Tumor growth, degree of proliferation, tumor morphology, and the presence of extrahepatic metastases were investigated 21 days post-tumor induction. Results. The late phase of liver regeneration plays a significant role in tumor stimulation and metastasis. The degree of hepatectomy also appears to be an important factor. The degree of hepatic resection significantly influences tumor growth and the extent of extrahepatic metastases, particularly in the lungs. Conclusions. Elucidation of the processes involved in the late phase of liver regeneration may assist in the development and timing of adjuvant agents to minimize tumor recurrence during this phase.
Original languageEnglish
Pages (from-to)284 - 290
Number of pages7
JournalJournal of Surgical Research
Volume138
Issue number2
DOIs
Publication statusPublished - 2007
Externally publishedYes

Cite this

Harun, Nadia ; Nikfarjam, Mehrdad ; Muralidharan, Vijayaragavan ; Christophi, Christopher. / Liver regeneration stimulates tumor metastases. In: Journal of Surgical Research. 2007 ; Vol. 138, No. 2. pp. 284 - 290.
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title = "Liver regeneration stimulates tumor metastases",
abstract = "Background. Partial hepatectomy for patients with colorectal liver metastases is associated with a tumor recurrence rate approaching 80 post-resection. Different factors and phases associated with regeneration of the liver are implicated in tumor recurrence. This study investigates the effects of the early and late phases of liver regeneration and the impact of the degree of liver resection on stimulating tumor growth and metastasis. Materials and methods. Groups of mice underwent partial hepatectomy (37 or 70 ) and were then challenged with colorectal liver carcinoma (CRC) tumors immediately after liver resection (early and late phase effect) or 6 days post liver resection (late phase effect). Tumor growth, degree of proliferation, tumor morphology, and the presence of extrahepatic metastases were investigated 21 days post-tumor induction. Results. The late phase of liver regeneration plays a significant role in tumor stimulation and metastasis. The degree of hepatectomy also appears to be an important factor. The degree of hepatic resection significantly influences tumor growth and the extent of extrahepatic metastases, particularly in the lungs. Conclusions. Elucidation of the processes involved in the late phase of liver regeneration may assist in the development and timing of adjuvant agents to minimize tumor recurrence during this phase.",
author = "Nadia Harun and Mehrdad Nikfarjam and Vijayaragavan Muralidharan and Christopher Christophi",
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Liver regeneration stimulates tumor metastases. / Harun, Nadia; Nikfarjam, Mehrdad; Muralidharan, Vijayaragavan; Christophi, Christopher.

In: Journal of Surgical Research, Vol. 138, No. 2, 2007, p. 284 - 290.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Liver regeneration stimulates tumor metastases

AU - Harun, Nadia

AU - Nikfarjam, Mehrdad

AU - Muralidharan, Vijayaragavan

AU - Christophi, Christopher

PY - 2007

Y1 - 2007

N2 - Background. Partial hepatectomy for patients with colorectal liver metastases is associated with a tumor recurrence rate approaching 80 post-resection. Different factors and phases associated with regeneration of the liver are implicated in tumor recurrence. This study investigates the effects of the early and late phases of liver regeneration and the impact of the degree of liver resection on stimulating tumor growth and metastasis. Materials and methods. Groups of mice underwent partial hepatectomy (37 or 70 ) and were then challenged with colorectal liver carcinoma (CRC) tumors immediately after liver resection (early and late phase effect) or 6 days post liver resection (late phase effect). Tumor growth, degree of proliferation, tumor morphology, and the presence of extrahepatic metastases were investigated 21 days post-tumor induction. Results. The late phase of liver regeneration plays a significant role in tumor stimulation and metastasis. The degree of hepatectomy also appears to be an important factor. The degree of hepatic resection significantly influences tumor growth and the extent of extrahepatic metastases, particularly in the lungs. Conclusions. Elucidation of the processes involved in the late phase of liver regeneration may assist in the development and timing of adjuvant agents to minimize tumor recurrence during this phase.

AB - Background. Partial hepatectomy for patients with colorectal liver metastases is associated with a tumor recurrence rate approaching 80 post-resection. Different factors and phases associated with regeneration of the liver are implicated in tumor recurrence. This study investigates the effects of the early and late phases of liver regeneration and the impact of the degree of liver resection on stimulating tumor growth and metastasis. Materials and methods. Groups of mice underwent partial hepatectomy (37 or 70 ) and were then challenged with colorectal liver carcinoma (CRC) tumors immediately after liver resection (early and late phase effect) or 6 days post liver resection (late phase effect). Tumor growth, degree of proliferation, tumor morphology, and the presence of extrahepatic metastases were investigated 21 days post-tumor induction. Results. The late phase of liver regeneration plays a significant role in tumor stimulation and metastasis. The degree of hepatectomy also appears to be an important factor. The degree of hepatic resection significantly influences tumor growth and the extent of extrahepatic metastases, particularly in the lungs. Conclusions. Elucidation of the processes involved in the late phase of liver regeneration may assist in the development and timing of adjuvant agents to minimize tumor recurrence during this phase.

UR - http://www.ncbi.nlm.nih.gov/pubmed/17254608

U2 - 10.1016/j.jss.2006.06.024

DO - 10.1016/j.jss.2006.06.024

M3 - Article

VL - 138

SP - 284

EP - 290

JO - Journal of Surgical Research

JF - Journal of Surgical Research

SN - 0022-4804

IS - 2

ER -