Liver regeneration and tumor stimulation-A review of cytokine and angiogenic factors

Christopher Christophi, Nadia Harun, Theodora Fifis

Research output: Contribution to journalArticleResearchpeer-review

37 Citations (Scopus)

Abstract

Liver resection for metastatic (colorectal carcinoma) tumors is often followed by a significant incidence of tumor recurrence. Cellular and molecular changes resulting from hepatectomy and the subsequent liver regeneration process may influence the kinetics of tumor growth and contribute to recurrence. Clinical and experimental evidence suggests that factors involved in liver regeneration may also stimulate the growth of occult tumors and the reactivation of dormant micrometastases. An understanding of the underlying changes may enable alternative strategies to minimize tumor recurrence and improve patient survival after hepatectomy.
Original languageEnglish
Pages (from-to)966 - 980
Number of pages15
JournalJournal of Gastrointestinal Surgery
Volume12
Issue number5
DOIs
Publication statusPublished - 2008
Externally publishedYes

Cite this

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Liver regeneration and tumor stimulation-A review of cytokine and angiogenic factors. / Christophi, Christopher; Harun, Nadia; Fifis, Theodora.

In: Journal of Gastrointestinal Surgery, Vol. 12, No. 5, 2008, p. 966 - 980.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Liver regeneration and tumor stimulation-A review of cytokine and angiogenic factors

AU - Christophi, Christopher

AU - Harun, Nadia

AU - Fifis, Theodora

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N2 - Liver resection for metastatic (colorectal carcinoma) tumors is often followed by a significant incidence of tumor recurrence. Cellular and molecular changes resulting from hepatectomy and the subsequent liver regeneration process may influence the kinetics of tumor growth and contribute to recurrence. Clinical and experimental evidence suggests that factors involved in liver regeneration may also stimulate the growth of occult tumors and the reactivation of dormant micrometastases. An understanding of the underlying changes may enable alternative strategies to minimize tumor recurrence and improve patient survival after hepatectomy.

AB - Liver resection for metastatic (colorectal carcinoma) tumors is often followed by a significant incidence of tumor recurrence. Cellular and molecular changes resulting from hepatectomy and the subsequent liver regeneration process may influence the kinetics of tumor growth and contribute to recurrence. Clinical and experimental evidence suggests that factors involved in liver regeneration may also stimulate the growth of occult tumors and the reactivation of dormant micrometastases. An understanding of the underlying changes may enable alternative strategies to minimize tumor recurrence and improve patient survival after hepatectomy.

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JF - Journal of Gastrointestinal Surgery

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