Live Salmonella as vaccines and carriers of foreign antigenic determinants

Steven N. Chatfield, Richard A. Strugnell, Gordon Dougan

Research output: Contribution to journalShort SurveyResearchpeer-review

Abstract

Salmonella species can be rationally attenuated by introducing non-reverting defined mutations into the genome to produce live vaccine strains. Several genes have been identified which when mutated, will attenuate Salmonellae. In particular, salmonella strains harbouring mutations in genes involved in the pre-chorismate biosynthetic pathway make excellent oral vaccines evoking strong humoral, local and cellular immune responses in the host. Because of the spectrum of immune responses induced by live vaccine strains they have the potential to be used for delivery of heterologous antigens to the mammalian immune system. A number of antigens from other bacteria, viruses and parasites have been expressed in live salmonella vaccine strains. Such hybrid strains have the potential to be used as multivalent vaccines against a number of infectious diseases.

Original languageEnglish
Pages (from-to)495-498
Number of pages4
JournalVaccine
Volume7
Issue number6
DOIs
Publication statusPublished - 1 Jan 1989
Externally publishedYes

Keywords

  • Salmonella spp, live vaccine
  • vector

Cite this

Chatfield, Steven N. ; Strugnell, Richard A. ; Dougan, Gordon. / Live Salmonella as vaccines and carriers of foreign antigenic determinants. In: Vaccine. 1989 ; Vol. 7, No. 6. pp. 495-498.
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Live Salmonella as vaccines and carriers of foreign antigenic determinants. / Chatfield, Steven N.; Strugnell, Richard A.; Dougan, Gordon.

In: Vaccine, Vol. 7, No. 6, 01.01.1989, p. 495-498.

Research output: Contribution to journalShort SurveyResearchpeer-review

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