Live birth rates after combined adjuvant therapy in IVF-ICSI cycles: a matched case-control study

Caroline Motteram, Beverley Janine Vollenhoven, Nicole Hope, Tiki Osianlis, Luk Rombauts

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)


The effectiveness of combined co-treatment with aspirin, doxycycline, prednisolone, with or without oestradiol patches, was investigated on live birth (LBR) rates after fresh and frozen embryo transfers (FET) in IVF and intracytoplasmic sperm injection cycles. Cases (n = 485) and controls (n = 485) were extensively matched in a one-to-one ratio on nine physical and clinical parameters: maternal age, body mass index, smoking status, stimulation cycle number, cumulative dose of FSH, stimulation protocol, insemination method, day of embryo transfer and number of embryos transferred. No significant differences were found in fresh cycles between cases and controls for the pregnancy outcomes analysed, but fewer surplus embryos were available for freezing in the combined adjuvant group. In FET cycles, LBR was lower in the treatment group (OR: 0.49, 95 CI 0.25 to 0.95). The lower LBR in FET cycles seemed to be clustered in patients receiving combined adjuvant treatment without luteal oestradiol (OR 0.37, 95 CI 0.17 to 0.80). No difference was found in LBR between cases and controls when stratified according to the number of previous cycles (
Original languageEnglish
Pages (from-to)340 - 348
Number of pages9
JournalReproductive BioMedicine Online
Issue number4
Publication statusPublished - 2015

Cite this