Lithium alkyl(hydro)dipinan-3α-ylborates. New reagents for asymmetric reduction of ketones

M. F. Grundon, W. A. Khan, D. R. Boyd, W. R. Jackson

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Abstract

The preparation and characterisation of a new class of reducing agents, lithium alkyl(hydro)dipinan-3α-ylborates, is described. These reagents have been used to reduce a series of ketones (of the type RCOR′) to optically active alcohols with optical yields in the range 5-45%. The stereochemistry of reduction of a series of substituted cyclohexanones is discussed.

Original languageEnglish
Pages (from-to)2557-2559
Number of pages3
JournalJournal of the Chemical Society C: Organic Chemistry
DOIs
Publication statusPublished - 1 Dec 1971
Externally publishedYes

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