Liquid forms of pharmaceutical co-crystals: exploring the boundaries of salt formation

Katharina Bica, Julia Shamshina, Whitney Hough, Douglas Macfarlane, Robin Rogers

Research output: Contribution to journalArticleResearchpeer-review

86 Citations (Scopus)


We present evidence of hydrogen bond formation, not salt formation, as the driving force in the liquefaction of a solid pharmaceutical in the form of a neutral acid-base complex, as exemplified by the liquid formed from a mixture of the local anesthetic lidocaine with fatty acids; these complexes exist at the boundary between simple eutectics and partially ionised ionic liquids.
Original languageEnglish
Pages (from-to)2267 - 2269
Number of pages3
JournalChemical Communications
Issue number8
Publication statusPublished - 2011

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