Liquid biopsy: an evolving paradigm for the biological characterisation of plasma cell disorders

Sridurga Mithraprabhu, Maoshan Chen, Ioanna Savvidou, Antonia Reale, Andrew Spencer

Research output: Contribution to journalReview ArticleResearchpeer-review

23 Citations (Scopus)

Abstract

Liquid biopsies—a source of circulating cell-free nucleic acids, proteins and extracellular vesicles—are currently being explored for the quantitative and qualitative characterisation of the tumour genome and as a mode of non-invasive therapeutic monitoring in cancer. Emerging data suggest that liquid biopsies might offer a potentially simple, non-invasive, repeatable strategy for diagnosis, prognostication and therapeutic decision making in a genetically heterogeneous disease like multiple myeloma (MM), with particular applicability in subsets of patients where conventional markers of disease burden may be less informative. In this review, we describe the emerging utility of the evaluation of circulating tumour DNA, extracellular RNA, cell-free proteins and metabolites and extracellular vesicles in MM.

Original languageEnglish
Pages (from-to)2771-2783
Number of pages13
JournalLeukemia
Volume35
Issue number10
DOIs
Publication statusPublished - Oct 2021

Cite this