TY - JOUR
T1 - Liquid biopsies for liquid tumors
T2 - Emerging potential of circulating free nucleic acid evaluation for the management of hematologic malignancies
AU - Hocking, Jay
AU - Mithraprabhu, Sridurga
AU - Kalff, Anna
AU - Spencer, Andrew
PY - 2016/6/1
Y1 - 2016/6/1
N2 - Circulating free nucleic acids; cell free DNA and circulating micro-RNA, are found in the plasma of patients with hematologic and solid malignancies at levels higher than that of healthy individuals. In patients with hematologic malignancy cell free DNA reflects the underlying tumor mutational profile, whilst micro-RNAs reflect genetic interference mechanisms within a tumor and potentially the surrounding microenvironment and immune effector cells. These circulating nucleic acids offer a potentially simple, non-invasive, repeatable analysis that can aid in diagnosis, prognosis and therapeutic decisions in cancer treatment.
AB - Circulating free nucleic acids; cell free DNA and circulating micro-RNA, are found in the plasma of patients with hematologic and solid malignancies at levels higher than that of healthy individuals. In patients with hematologic malignancy cell free DNA reflects the underlying tumor mutational profile, whilst micro-RNAs reflect genetic interference mechanisms within a tumor and potentially the surrounding microenvironment and immune effector cells. These circulating nucleic acids offer a potentially simple, non-invasive, repeatable analysis that can aid in diagnosis, prognosis and therapeutic decisions in cancer treatment.
KW - Biopsy
KW - Circulating nucleic acids
KW - DNA
KW - Hematologic malignancy
KW - MiRNA
UR - http://www.scopus.com/inward/record.url?scp=84978829525&partnerID=8YFLogxK
U2 - 10.20892/j.issn.2095-3941.2016.0025
DO - 10.20892/j.issn.2095-3941.2016.0025
M3 - Review Article
AN - SCOPUS:84978829525
SN - 2095-3941
VL - 13
SP - 215
EP - 225
JO - Cancer Biology and Medicine
JF - Cancer Biology and Medicine
IS - 2
ER -
