Liquid Assisted Grinding for the N-Demethylation of Alkaloids

Jon Kyle Awalt, Peter J. Scammells, Robert D. Singer

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)


Copyright © 2018 American Chemical Society. A mechanochemical approach has been demonstrated for the selective cleavage of nitrogen-carbon bonds in the N-demethylation of various alkaloids relevant in the pharmaceutical industry. This methodology employs a range of so-called "liquid additives" used in microliter quantities in liquid assisted grinding rather than "solvents" used in solution phase reactions. Green liquid additives such as alcohols, water, PEG and ionic liquids as well as a nonchemical, mechanical approach for the generation of nanoscale Fe0dust significantly improve the green attributes of the N-demethylation process.
Original languageEnglish
Pages (from-to)10052-10057
Number of pages6
JournalACS Sustainable Chemistry & Engineering
Issue number8
Publication statusPublished - 6 Aug 2018


  • Alkaloid
  • Liquid additive
  • Liquid assisted grinding
  • Mechanochemistry
  • N-Demethylation

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