Liposomes as Systemic and Mucosal Delivery Vehicles

Jim Dimitrios Vadolas, Odilia LC Wijburg, Richard A Strugnell

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Liposomes are microscopic, spherical phospholipid bilayers which contain an aqueous internal environment They were first described by Bangham et al. (1965), who demonstrated that liposomes could entrap solutes such as cations and anions. In these studies it was revealed that liposomes containing entrapped anions, Cl−, and I−, were shown to be more permeable than liposomes containing entrapped cations, such as Na+ and K+. Subsequent work identified the utility of liposomes in drug delivery and liposomes have since been used to administer a wide range of pharmaceutical compounds such as anti-microbial and anti-cancer agents. Entrapment of drugs into liposomes often resulted in reduced toxicity and prolonged circulation time compared with the drug alone. Licensed products include AmBisomes® and Abelcet® which contain amphotericin B in a liposome formulation, for the treatment of systemic fungal infections, and DOX-SL® and DaunoXome® which respectively contain doxorubicin and daunorubicin in a liposome formulation for the treatment of Karposi’s sarcoma.
Original languageEnglish
Title of host publicationAntigen Delivery Systems
Subtitle of host publicationImmunological and Technological Issues
EditorsBruno Gander, Hans P Merkle, Giampietro Corradin
Place of PublicationAmsterdam, The Netherlands
PublisherHarwood Academic Publishers
Chapter6
Pages108-147
Number of pages40
ISBN (Electronic)9780203304341
Publication statusPublished - 2003
Externally publishedYes

Cite this

Vadolas, J. D., Wijburg, O. LC., & Strugnell, R. A. (2003). Liposomes as Systemic and Mucosal Delivery Vehicles. In B. Gander, H. P. Merkle, & G. Corradin (Eds.), Antigen Delivery Systems: Immunological and Technological Issues (pp. 108-147). Harwood Academic Publishers. https://www.taylorfrancis.com/books/e/9780203304341/chapters/10.3109%2F9780203304341-12