Liposomal amphotericin B

Nenad Macesic; Neil R.H. Stone; John R. Wingard

Liposomal amphotericin B

Nenad Macesic, Neil R.H. Stone, John R. Wingard

Research output: Chapter in Book/Report/Conference proceeding › Chapter (Book) › Other › peer-review

Abstract

The widespread use of amphotericin B deoxycholate (DAmB) is limited because of both infusional toxicity and nephrotoxicity. These inherent limitations were the primary motivation to develop lipid formulations of AmB that are safer, but still retain potent antifungal activity. Liposomal amphotericin B consists of true liposomes that are approximately 80 nm in diameter, that contain various lipids and the amphipathic amphotericin B embedded in the wall of the liposome. Liposomal amphotericin B (LAmB) is widely available and has an extensive usage and safety database (Figure 142.1).

Original language	English
Title of host publication	Kucers the Use of Antibiotics
Subtitle of host publication	A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, Seventh Edition
Publisher	CRC Press
Pages	2612-2627
Number of pages	16
ISBN (Electronic)	9781498747967
ISBN (Print)	9781498747950
Publication status	Published - 1 Jan 2017
Externally published	Yes

Cite this

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AB - The widespread use of amphotericin B deoxycholate (DAmB) is limited because of both infusional toxicity and nephrotoxicity. These inherent limitations were the primary motivation to develop lipid formulations of AmB that are safer, but still retain potent antifungal activity. Liposomal amphotericin B consists of true liposomes that are approximately 80 nm in diameter, that contain various lipids and the amphipathic amphotericin B embedded in the wall of the liposome. Liposomal amphotericin B (LAmB) is widely available and has an extensive usage and safety database (Figure 142.1).

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ER -

Liposomal amphotericin B

Abstract

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