TY - JOUR
T1 - Lipopolysaccharide, immune activation, and liver abnormalities in HIV/hepatitis B virus (HBV)-coinfected individuals receiving HBV-active combination antiretroviral therapy
AU - Crane, Megan
AU - Avihingsanon, Anchalee
AU - Rajasuriar, Reena
AU - Velayudham, Pushparaj
AU - Iser, David
AU - Solomon, Ajantha
AU - Sebolao, Baotuti
AU - Tran, Andrew
AU - Spelman, Tim
AU - Matthews, Gail V
AU - Cameron, Paul Urquhart
AU - Tangkijvanich, Pisit
AU - Dore, Gregory J
AU - Ruxrungtham, Kiat
AU - Lewin, Sharon Ruth
PY - 2014
Y1 - 2014
N2 - We investigated the relationship between microbial translocation, immune activation, and liver disease in human immunodeficiency virus (HIV)/hepatitis B virus (HBV) coinfection. Lipopolysaccharide (LPS), soluble CD14, CXCL10, and CCL-2 levels were elevated in patients with HIV/HBV coinfection. Levels of LPS, soluble CD14, and CCL-2 declined following receipt of HBV-active combination antiretroviral therapy (cART), but the CXCL10 level remained elevated. No markers were associated with liver disease severity on liver biopsy (n = 96), but CXCL10, interleukin 6 (IL-6), interleukin 10 (IL-10), tumor necrosis factor a, and interferon ? (IFN-?) were all associated with elevated liver enzyme levels during receipt of HBV-active cART. Stimulation of hepatocyte cell lines in vitro with IFN-? and LPS induced a profound synergistic increase in the production of CXCL10. LPS may contribute to liver disease via stimulating persistent production of CXCL10.
AB - We investigated the relationship between microbial translocation, immune activation, and liver disease in human immunodeficiency virus (HIV)/hepatitis B virus (HBV) coinfection. Lipopolysaccharide (LPS), soluble CD14, CXCL10, and CCL-2 levels were elevated in patients with HIV/HBV coinfection. Levels of LPS, soluble CD14, and CCL-2 declined following receipt of HBV-active combination antiretroviral therapy (cART), but the CXCL10 level remained elevated. No markers were associated with liver disease severity on liver biopsy (n = 96), but CXCL10, interleukin 6 (IL-6), interleukin 10 (IL-10), tumor necrosis factor a, and interferon ? (IFN-?) were all associated with elevated liver enzyme levels during receipt of HBV-active cART. Stimulation of hepatocyte cell lines in vitro with IFN-? and LPS induced a profound synergistic increase in the production of CXCL10. LPS may contribute to liver disease via stimulating persistent production of CXCL10.
UR - http://jid.oxfordjournals.org/content/210/5/745.full.pdf
U2 - 10.1093/infdis/jiu119
DO - 10.1093/infdis/jiu119
M3 - Article
VL - 210
SP - 745
EP - 751
JO - The Journal of Infectious Diseases
JF - The Journal of Infectious Diseases
SN - 0022-1899
IS - 5
ER -
