TY - JOUR
T1 - Lipophilicity in Drug Development
T2 - Too Much or Not Enough?
AU - Bergström, Christel A.S.
AU - Yazdanian, Mehran
PY - 2016/9/1
Y1 - 2016/9/1
N2 - A round table discussion was held during the AAPS Annual Meeting on October 27, 2015, with the somewhat provocative topic of whether we need more or less lipophilic compounds in drug development. The session was attended by more than 250 participants, and the feedback was very positive as this round table became a forum for the exchange of ideas from scientists within the academia and industry. Most importantly, the discussion highlighted the difference in approaches to compound selection and development strategies in various companies and organizations. As moderators of this session, we are writing this report to highlight the points and counterpoints made at the session and to bring the importance of the dialogue and debate to the forefront of discussions on how to select the best drug development candidates to enable efficient delivery and, hence, treatment of diseases.
AB - A round table discussion was held during the AAPS Annual Meeting on October 27, 2015, with the somewhat provocative topic of whether we need more or less lipophilic compounds in drug development. The session was attended by more than 250 participants, and the feedback was very positive as this round table became a forum for the exchange of ideas from scientists within the academia and industry. Most importantly, the discussion highlighted the difference in approaches to compound selection and development strategies in various companies and organizations. As moderators of this session, we are writing this report to highlight the points and counterpoints made at the session and to bring the importance of the dialogue and debate to the forefront of discussions on how to select the best drug development candidates to enable efficient delivery and, hence, treatment of diseases.
UR - http://www.scopus.com/inward/record.url?scp=84978112672&partnerID=8YFLogxK
U2 - 10.1208/s12248-016-9947-5
DO - 10.1208/s12248-016-9947-5
M3 - Article
C2 - 27393481
AN - SCOPUS:84978112672
VL - 18
SP - 1095
EP - 1100
JO - The AAPS Journal
JF - The AAPS Journal
SN - 1550-7416
IS - 5
ER -