Lipocortin-1 preserves myocardial responsiveness to β-adrenergic stimulation in rat papillary muscle

Rebecca H. Ritchie, Sun Xiaolu, Gregory J. Dusting

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6 Citations (Scopus)

Abstract

1. During septic shock, myocardial contractile dysfunction is accompanied by the release of cytokines and enhanced production of nitric oxide, and the contractile dysfunction is prevented by glucocorticoids. 2. Myocardial dysfunction was induced in vitro by incubation of rat papillary muscle for 15 h with endotoxin (lipopolysaccharide, LPS) and interferon-γ (IFN-γ). 3. Both baseline contractile function and inotropic responsiveness to isoprenaline were markedly reduced by the combination of LPS plus IFN-γ. 4. Lipocortin-1 (LC-1) is induced by glucocorticoids, and LC-12-26, its N-terminal fragment, protected the papillary muscle inotropic responsiveness to isoprenaline, but did not affect the decline in baseline contractile function induced by LPS plus IFN-γ. 5. The mechanisms of this protective action need to be explored further, but LC-1 may prove to be a novel cardio- protective agent for the management of septic shock.

Original languageEnglish
Pages (from-to)522-524
Number of pages3
JournalClinical and Experimental Pharmacology and Physiology
Volume26
Issue number7
DOIs
Publication statusPublished - 14 Jul 1999
Externally publishedYes

Keywords

  • Endotoxin
  • Interferon-γ
  • Isoprenaline
  • Lipocortin-1
  • Papillary muscle

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