Lipids in oral controlled release drug delivery

Benjamin Boyd, Tri-Hung Nguyen, Anette Mullertz

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review


Lipids can perform many useful functions that modify or otherwise enhance drug absorption or disposition. They may influence release/absorption-controlling processes, such as gastro retention and muco-adhesion. They can facilitate lymphatic transport of lipophilic drugs, and make them less susceptible to first pass effects by avoiding or reducing the hepatic portal route. Understanding lipid digestion and structure formation in vivo is key to exploiting possibilities for their use in controlling absorption or disposition. In particular, liquid crystalline structures are being increasingly investigated for their roles in the aforementioned processes. Such phenomena and possibilities are discussed in this chapter.
Original languageEnglish
Title of host publicationControlled Release in Oral Drug Delivery
EditorsClive G Wilson, Patrick J Crowley
Place of PublicationUSA
Pages299 - 327
Number of pages29
ISBN (Print)9781461410034
Publication statusPublished - 2011

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