TY - JOUR
T1 - Lipids and diabetic renal disease
AU - Cooper, Mark E.
AU - Jandeleit-Dahm, Karin A.M.
PY - 2005/1/1
Y1 - 2005/1/1
N2 - Diabetic nephropathy is commonly associated with dyslipidemia, but the role of lipids in the progression of this disorder remains unresolved. In particular, the role of lipid-lowering drugs, such as 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and fibrates, as renoprotective agents is not clarified. Experimental studies have demonstrated that dietary lipids promote renal injury and that statins, independent of their lipid-lowering effects, confer renoprotection via effects on intrarenal hemodynamics and renal cytokine and chemokine expression. Clinical studies have in general been underpowered, but a recent meta-analysis and findings from the Heart Protection Study suggest that statins may be renoprotective. Nevertheless, with the convincing antiatherosclerotic effects of these agents, including in the setting of diabetes, they should be widely administered in the diabetic population with or at risk for nephropathy.
AB - Diabetic nephropathy is commonly associated with dyslipidemia, but the role of lipids in the progression of this disorder remains unresolved. In particular, the role of lipid-lowering drugs, such as 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors and fibrates, as renoprotective agents is not clarified. Experimental studies have demonstrated that dietary lipids promote renal injury and that statins, independent of their lipid-lowering effects, confer renoprotection via effects on intrarenal hemodynamics and renal cytokine and chemokine expression. Clinical studies have in general been underpowered, but a recent meta-analysis and findings from the Heart Protection Study suggest that statins may be renoprotective. Nevertheless, with the convincing antiatherosclerotic effects of these agents, including in the setting of diabetes, they should be widely administered in the diabetic population with or at risk for nephropathy.
UR - http://www.scopus.com/inward/record.url?scp=29644442097&partnerID=8YFLogxK
U2 - 10.1007/s11892-005-0053-9
DO - 10.1007/s11892-005-0053-9
M3 - Review Article
C2 - 16316596
AN - SCOPUS:29644442097
SN - 1534-4827
VL - 5
SP - 445
EP - 448
JO - Current Diabetes Reports
JF - Current Diabetes Reports
IS - 6
ER -