Abstract
Lipids are a diverse class of hydrophobic and amphiphilic molecules which make up the bulk of most biological systems and are essential for human life. The role of lipids in health and disease has been recognized for many decades, as evidenced by the early identification of cholesterol as an important risk factor of heart disease and the development and introduction of statins as a one of the most successful therapeutic interventions to date. While several studies have demonstrated an increased risk of dementia, including Alzheimer's disease (AD), in those with diabetes mellitus, the nature of this risk is not well understood. Recent developments in the field of lipidomics, driven primarily by technological advances in high pressure liquid chromatography and particularly mass spectrometry, have enabled the detailed characterization of the many hundreds of individual lipid species in mammalian systems and their association with disease states. Diabetes mellitus and AD have received particular attention due to their prominence in Western societies as a result of the ongoing obesity epidemic and the aging populations. In this review, we examine how these lipidomic studies are informing on the relationship between lipid metabolism with diabetes and AD and how this may inform on the common pathological pathways that link diabetes risk with dementia.
| Original language | English |
|---|---|
| Pages (from-to) | 433-444 |
| Number of pages | 12 |
| Journal | Journal of Alzheimer's Disease |
| Volume | 59 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2017 |
Keywords
- Alzheimer's disease
- diabetes mellitus
- lipid metabolism
- mass spectrometry
- risk
Cite this
}
Lipidomic Profiles in Diabetes and Dementia. / Huynh, Kevin; Martins, Ralph N.; Meikle, Peter J.
In: Journal of Alzheimer's Disease, Vol. 59, No. 2, 2017, p. 433-444.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - Lipidomic Profiles in Diabetes and Dementia
AU - Huynh, Kevin
AU - Martins, Ralph N.
AU - Meikle, Peter J.
PY - 2017
Y1 - 2017
N2 - Lipids are a diverse class of hydrophobic and amphiphilic molecules which make up the bulk of most biological systems and are essential for human life. The role of lipids in health and disease has been recognized for many decades, as evidenced by the early identification of cholesterol as an important risk factor of heart disease and the development and introduction of statins as a one of the most successful therapeutic interventions to date. While several studies have demonstrated an increased risk of dementia, including Alzheimer's disease (AD), in those with diabetes mellitus, the nature of this risk is not well understood. Recent developments in the field of lipidomics, driven primarily by technological advances in high pressure liquid chromatography and particularly mass spectrometry, have enabled the detailed characterization of the many hundreds of individual lipid species in mammalian systems and their association with disease states. Diabetes mellitus and AD have received particular attention due to their prominence in Western societies as a result of the ongoing obesity epidemic and the aging populations. In this review, we examine how these lipidomic studies are informing on the relationship between lipid metabolism with diabetes and AD and how this may inform on the common pathological pathways that link diabetes risk with dementia.
AB - Lipids are a diverse class of hydrophobic and amphiphilic molecules which make up the bulk of most biological systems and are essential for human life. The role of lipids in health and disease has been recognized for many decades, as evidenced by the early identification of cholesterol as an important risk factor of heart disease and the development and introduction of statins as a one of the most successful therapeutic interventions to date. While several studies have demonstrated an increased risk of dementia, including Alzheimer's disease (AD), in those with diabetes mellitus, the nature of this risk is not well understood. Recent developments in the field of lipidomics, driven primarily by technological advances in high pressure liquid chromatography and particularly mass spectrometry, have enabled the detailed characterization of the many hundreds of individual lipid species in mammalian systems and their association with disease states. Diabetes mellitus and AD have received particular attention due to their prominence in Western societies as a result of the ongoing obesity epidemic and the aging populations. In this review, we examine how these lipidomic studies are informing on the relationship between lipid metabolism with diabetes and AD and how this may inform on the common pathological pathways that link diabetes risk with dementia.
KW - Alzheimer's disease
KW - diabetes mellitus
KW - lipid metabolism
KW - mass spectrometry
KW - risk
UR - http://www.scopus.com/inward/record.url?scp=85024859813&partnerID=8YFLogxK
U2 - 10.3233/JAD-161215
DO - 10.3233/JAD-161215
M3 - Review Article
VL - 59
SP - 433
EP - 444
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
SN - 1387-2877
IS - 2
ER -