Lipidomic dataset of plasma from patients infected with wild type and nef-deficient HIV-1 strain

Peter Meikle, Hann Low, Melissa J. Churchill, Michael Bukrinsky, Dmitri Sviridov

Research output: Contribution to journalArticleOtherpeer-review

Abstract

Previous in vitro and in vivo studies demonstrated that HIV protein nef plays a key role in impairing cellular and systemic cholesterol metabolism in HIV disease, but clinical support for these findings is lacking. Here we present the data of comparative lipidomic analysis (330 lipid species) of plasma samples from HIV-negative subjects, patients infected with WT HIV-1 strain and patients infected with nef-deficient strain of HIV-1. We determine which effects of HIV on plasma lipidome are explained by the presence of nef. The data can be used to evaluate cardiovascular risk in HIV disease and to assess the role of nef in HIV-induced disturbances in systemic lipid metabolism. The full impact of nef deficiency on lipid and lipoprotein metabolism in HIV-infected patients is presented in the accompanying study "Lipid Metabolism in Patients Infected with Nef-deficient HIV-1 Strain" [1].

Original languageEnglish
Pages (from-to)168-175
Number of pages8
JournalData in Brief
Volume6
DOIs
Publication statusPublished - 1 Mar 2016
Externally publishedYes

Cite this

Meikle, Peter ; Low, Hann ; Churchill, Melissa J. ; Bukrinsky, Michael ; Sviridov, Dmitri. / Lipidomic dataset of plasma from patients infected with wild type and nef-deficient HIV-1 strain. In: Data in Brief. 2016 ; Vol. 6. pp. 168-175.
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Lipidomic dataset of plasma from patients infected with wild type and nef-deficient HIV-1 strain. / Meikle, Peter; Low, Hann; Churchill, Melissa J.; Bukrinsky, Michael; Sviridov, Dmitri.

In: Data in Brief, Vol. 6, 01.03.2016, p. 168-175.

Research output: Contribution to journalArticleOtherpeer-review

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