Abstract
Previous in vitro and in vivo studies demonstrated that HIV protein nef plays a key role in impairing cellular and systemic cholesterol metabolism in HIV disease, but clinical support for these findings is lacking. Here we present the data of comparative lipidomic analysis (330 lipid species) of plasma samples from HIV-negative subjects, patients infected with WT HIV-1 strain and patients infected with nef-deficient strain of HIV-1. We determine which effects of HIV on plasma lipidome are explained by the presence of nef. The data can be used to evaluate cardiovascular risk in HIV disease and to assess the role of nef in HIV-induced disturbances in systemic lipid metabolism. The full impact of nef deficiency on lipid and lipoprotein metabolism in HIV-infected patients is presented in the accompanying study "Lipid Metabolism in Patients Infected with Nef-deficient HIV-1 Strain" [1].
| Original language | English |
|---|---|
| Pages (from-to) | 168-175 |
| Number of pages | 8 |
| Journal | Data in Brief |
| Volume | 6 |
| DOIs | |
| Publication status | Published - 1 Mar 2016 |
| Externally published | Yes |
Cite this
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Lipidomic dataset of plasma from patients infected with wild type and nef-deficient HIV-1 strain. / Meikle, Peter; Low, Hann; Churchill, Melissa J.; Bukrinsky, Michael; Sviridov, Dmitri.
In: Data in Brief, Vol. 6, 01.03.2016, p. 168-175.Research output: Contribution to journal › Article › Other › peer-review
TY - JOUR
T1 - Lipidomic dataset of plasma from patients infected with wild type and nef-deficient HIV-1 strain
AU - Meikle, Peter
AU - Low, Hann
AU - Churchill, Melissa J.
AU - Bukrinsky, Michael
AU - Sviridov, Dmitri
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Previous in vitro and in vivo studies demonstrated that HIV protein nef plays a key role in impairing cellular and systemic cholesterol metabolism in HIV disease, but clinical support for these findings is lacking. Here we present the data of comparative lipidomic analysis (330 lipid species) of plasma samples from HIV-negative subjects, patients infected with WT HIV-1 strain and patients infected with nef-deficient strain of HIV-1. We determine which effects of HIV on plasma lipidome are explained by the presence of nef. The data can be used to evaluate cardiovascular risk in HIV disease and to assess the role of nef in HIV-induced disturbances in systemic lipid metabolism. The full impact of nef deficiency on lipid and lipoprotein metabolism in HIV-infected patients is presented in the accompanying study "Lipid Metabolism in Patients Infected with Nef-deficient HIV-1 Strain" [1].
AB - Previous in vitro and in vivo studies demonstrated that HIV protein nef plays a key role in impairing cellular and systemic cholesterol metabolism in HIV disease, but clinical support for these findings is lacking. Here we present the data of comparative lipidomic analysis (330 lipid species) of plasma samples from HIV-negative subjects, patients infected with WT HIV-1 strain and patients infected with nef-deficient strain of HIV-1. We determine which effects of HIV on plasma lipidome are explained by the presence of nef. The data can be used to evaluate cardiovascular risk in HIV disease and to assess the role of nef in HIV-induced disturbances in systemic lipid metabolism. The full impact of nef deficiency on lipid and lipoprotein metabolism in HIV-infected patients is presented in the accompanying study "Lipid Metabolism in Patients Infected with Nef-deficient HIV-1 Strain" [1].
UR - http://www.scopus.com/inward/record.url?scp=84961134478&partnerID=8YFLogxK
U2 - 10.1016/j.dib.2015.11.067
DO - 10.1016/j.dib.2015.11.067
M3 - Article
VL - 6
SP - 168
EP - 175
JO - Data in Brief
JF - Data in Brief
SN - 2352-3409
ER -