Lipid digestion as a trigger for supersaturation: evaluation of the impact of supersaturation stabilization on the in vitro and in vivo performance of self-emulsifying drug delivery systems

Mette Uhre Anby, Hywel David Williams, Michelle Paula McIntosh, Hassan Benameur, Glenn A Edwards, Colin William Pouton, Christopher John Porter

Research output: Contribution to journalArticleResearchpeer-review

100 Citations (Scopus)

Abstract

The generation of supersaturation in the gastrointestinal (GI) tract is an increasingly popular means of promoting oral absorption for poorly water-soluble drugs. The current study examined the impact of changes to the quantities of medium-chain (MC) lipid (Captex 300:Capmul MCM), surfactant (Cremophor EL) and cosolvent (EtOH), and the addition of polymeric precipitation inhibitors (PPI), on supersaturation during the dispersion and digestion of MC self-emulsifying drug delivery systems (SEDDS) containing danazol.
Original languageEnglish
Pages (from-to)2063 - 2079
Number of pages17
JournalMolecular Pharmaceutics
Volume9
Issue number9
DOIs
Publication statusPublished - 2012

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