TY - JOUR
T1 - Lipid digestion as a trigger for supersaturation: evaluation of the impact of supersaturation stabilization on the in vitro and in vivo performance of self-emulsifying drug delivery systems
AU - Anby, Mette Uhre
AU - Williams, Hywel David
AU - McIntosh, Michelle Paula
AU - Benameur, Hassan
AU - Edwards, Glenn A
AU - Pouton, Colin William
AU - Porter, Christopher John
PY - 2012
Y1 - 2012
N2 - The generation of supersaturation in the gastrointestinal (GI) tract is an increasingly popular means of promoting oral absorption for poorly water-soluble drugs. The current study examined the impact of changes to the quantities of medium-chain (MC) lipid (Captex 300:Capmul MCM), surfactant (Cremophor EL) and cosolvent (EtOH), and the addition of polymeric precipitation inhibitors (PPI), on supersaturation during the dispersion and digestion of MC self-emulsifying drug delivery systems (SEDDS) containing danazol.
AB - The generation of supersaturation in the gastrointestinal (GI) tract is an increasingly popular means of promoting oral absorption for poorly water-soluble drugs. The current study examined the impact of changes to the quantities of medium-chain (MC) lipid (Captex 300:Capmul MCM), surfactant (Cremophor EL) and cosolvent (EtOH), and the addition of polymeric precipitation inhibitors (PPI), on supersaturation during the dispersion and digestion of MC self-emulsifying drug delivery systems (SEDDS) containing danazol.
UR - http://pubs.acs.org/doi/abs/10.1021/mp300164u
U2 - 10.1021/mp300164u
DO - 10.1021/mp300164u
M3 - Article
SN - 1543-8384
VL - 9
SP - 2063
EP - 2079
JO - Molecular Pharmaceutics
JF - Molecular Pharmaceutics
IS - 9
ER -