Abstract
Integration of various theranostic modalities into one nanoplatform for combined treatment of tumor is highly desirable in the field of biomedicine. However, it is still challenging to engineer such a platform with good biocompatibility, multifunctionality, and response to external stimuli. Herein, biocompatible lipid bilayer modified mesoporous silica coated gold nanorods (AuNRs) nanocomposites were developed. The heat from near-infrared (NIR)-stimulated AuNR cores could improve the permeability of the lipid bilayer, thereby leading to drug release. The in vitro results exhibited the DOX loaded nanocomposites to have high treatment efficiency in HeLa cells upon NIR irradiation. They may find potential in cancer treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 8078-8084 |
| Number of pages | 7 |
| Journal | Journal of Materials Chemistry B |
| Volume | 6 |
| Issue number | 48 |
| DOIs | |
| Publication status | Published - 2018 |
Cite this
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Lipid bilayer modified gold nanorod@mesoporous silica nanoparticles for controlled drug delivery triggered by near-infrared light. / Cui, Xinyu; Cheng, Wenlong; Han, Xiaojun.
In: Journal of Materials Chemistry B, Vol. 6, No. 48, 2018, p. 8078-8084.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Lipid bilayer modified gold nanorod@mesoporous silica nanoparticles for controlled drug delivery triggered by near-infrared light
AU - Cui, Xinyu
AU - Cheng, Wenlong
AU - Han, Xiaojun
PY - 2018
Y1 - 2018
N2 - Integration of various theranostic modalities into one nanoplatform for combined treatment of tumor is highly desirable in the field of biomedicine. However, it is still challenging to engineer such a platform with good biocompatibility, multifunctionality, and response to external stimuli. Herein, biocompatible lipid bilayer modified mesoporous silica coated gold nanorods (AuNRs) nanocomposites were developed. The heat from near-infrared (NIR)-stimulated AuNR cores could improve the permeability of the lipid bilayer, thereby leading to drug release. The in vitro results exhibited the DOX loaded nanocomposites to have high treatment efficiency in HeLa cells upon NIR irradiation. They may find potential in cancer treatment.
AB - Integration of various theranostic modalities into one nanoplatform for combined treatment of tumor is highly desirable in the field of biomedicine. However, it is still challenging to engineer such a platform with good biocompatibility, multifunctionality, and response to external stimuli. Herein, biocompatible lipid bilayer modified mesoporous silica coated gold nanorods (AuNRs) nanocomposites were developed. The heat from near-infrared (NIR)-stimulated AuNR cores could improve the permeability of the lipid bilayer, thereby leading to drug release. The in vitro results exhibited the DOX loaded nanocomposites to have high treatment efficiency in HeLa cells upon NIR irradiation. They may find potential in cancer treatment.
UR - http://www.scopus.com/inward/record.url?scp=85058445617&partnerID=8YFLogxK
U2 - 10.1039/c8tb01891j
DO - 10.1039/c8tb01891j
M3 - Article
VL - 6
SP - 8078
EP - 8084
JO - Journal of Materials Chemistry B
JF - Journal of Materials Chemistry B
SN - 2050-750X
IS - 48
ER -