Projects per year
Abstract
COVID-19 vaccines have been developed with unprecedented speed which would not have been possible without decades of fundamental research on delivery nanotechnology. Lipid-based nanoparticles have played a pivotal role in the successes of COVID-19 vaccines and many other nanomedicines, such as Doxil® and Onpattro®, and have therefore been considered as the frontrunner in nanoscale drug delivery systems. In this review, we aim to highlight the progress in the development of these lipid nanoparticles for various applications, ranging from cancer nanomedicines to COVID-19 vaccines. The lipid-based nanoparticles discussed in this review are liposomes, niosomes, transfersomes, solid lipid nanoparticles, and nanostructured lipid carriers. We particularly focus on the innovations that have obtained regulatory approval or that are in clinical trials. We also discuss the physicochemical properties required for specific applications, highlight the differences in requirements for the delivery of different cargos, and introduce current challenges that need further development. This review serves as a useful guideline for designing new lipid nanoparticles for both preventative and therapeutic vaccines including immunotherapies.
Original language | English |
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Article number | 359 |
Number of pages | 29 |
Journal | Vaccines |
Volume | 9 |
Issue number | 4 |
DOIs | |
Publication status | Published - 8 Apr 2021 |
Keywords
- COVID-19
- Immunotherapy
- Lipid nanoparticles
- Liposomes
- Vaccines
Projects
- 3 Finished
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Developing smart nanomedicine to enable advanced diagnosis and stimuli-responsive treatment for atherosclerosis and thrombosis
Ta, H. (Primary Chief Investigator (PCI)) & Truong Phuoc, N. (Chief Investigator (CI))
1/01/21 → 31/12/23
Project: Research
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Bespoke nanomaterials for understanding nano-bio interactions under flow
Davis, T. (Primary Chief Investigator (PCI)), Truong Phuoc, N. (Chief Investigator (CI)), Kent, S. (Chief Investigator (CI)) & Anastasaki, A. (Partner Investigator (PI))
1/01/20 → 23/11/23
Project: Research
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Scalable synthesis of smart nanoworms with tailored properties
Truong Phuoc, N. (Primary Chief Investigator (PCI))
21/01/18 → 23/11/23
Project: Research