TY - JOUR
T1 - Lipid based nanocarriers system for topical delivery of photosensitizers
AU - Md, Shadab
AU - Haque, Shadabul
AU - Madheswaran, Thiagarajan
AU - Zeeshan, Farrukh
AU - Meka, Venkata Srikanth
AU - Radhakrishnan, Ammu K.
AU - Kesharwani, Prashant
PY - 2017/8
Y1 - 2017/8
N2 - Topical photodynamic therapy (PDT) is a non-invasive technique used in the treatment of malignant and non-malignant skin diseases. It offers great promise because of its simplicity, enhanced patient compliance, localisation of the photosensitizer, as well as the use of light and oxygen to achieve photocytotoxicity. Despite progress in photosensitizer-mediated topical PDT, its clinical application is limited by poor penetration of photosensitizers through the skin. Therefore, much effort has been made to develop nanocarriers that can tackle the challenges of conventional photosensitizer-mediated PDT for topical delivery. This review discusses recent data on the use of different types of lipid-based nanocarriers in delivering photosensitizer for topical PDT.
AB - Topical photodynamic therapy (PDT) is a non-invasive technique used in the treatment of malignant and non-malignant skin diseases. It offers great promise because of its simplicity, enhanced patient compliance, localisation of the photosensitizer, as well as the use of light and oxygen to achieve photocytotoxicity. Despite progress in photosensitizer-mediated topical PDT, its clinical application is limited by poor penetration of photosensitizers through the skin. Therefore, much effort has been made to develop nanocarriers that can tackle the challenges of conventional photosensitizer-mediated PDT for topical delivery. This review discusses recent data on the use of different types of lipid-based nanocarriers in delivering photosensitizer for topical PDT.
UR - http://www.scopus.com/inward/record.url?scp=85019135132&partnerID=8YFLogxK
U2 - 10.1016/j.drudis.2017.04.010
DO - 10.1016/j.drudis.2017.04.010
M3 - Review Article
C2 - 28456749
AN - SCOPUS:85019135132
SN - 1359-6446
VL - 22
SP - 1274
EP - 1283
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 8
ER -