Lipid-based formulations for oral administration: Opportunities for bioavailability enhancement and lipoprotein targeting of lipophilic drugs

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Abstract

The identification of increasingly complex intracellular drug targets, escalating requirements in terms of drug potency and the use of combinatorial chemistry libraries and in vitro receptor-based activity assays, has led to a trend toward the identification of increasingly lipophilic lead molecules. The clinical usefulness of highly lipophilic, poorly water-soluble drugs, however, is often limited by their low and variable oral bioavailability, and although co-administration with lipids, lipidic excipients, or fatty meals may improve the bioavailability of lipophilic drugs, the mechanistic aspects of this enhancement are incompletely understood.
Original languageEnglish
Title of host publicationDrug Targeting Technology
Subtitle of host publicationPhysical Chemical Biological Methods
EditorsHans Schreier
Place of PublicationBoca Raton FL USA
PublisherCRC Press
Chapter4
Pages85-130
Number of pages46
Volume115
ISBN (Electronic)9780203908563
ISBN (Print)9780824705800
Publication statusPublished - 2001

Publication series

NameDrugs and the pharmaceutical sciences: A Series of Textbooks and Monographs
PublisherCRC Press
Volume115

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