The identification of increasingly complex intracellular drug targets, escalating requirements in terms of drug potency and the use of combinatorial chemistry libraries and in vitro receptor-based activity assays, has led to a trend toward the identification of increasingly lipophilic lead molecules. The clinical usefulness of highly lipophilic, poorly water-soluble drugs, however, is often limited by their low and variable oral bioavailability, and although co-administration with lipids, lipidic excipients, or fatty meals may improve the bioavailability of lipophilic drugs, the mechanistic aspects of this enhancement are incompletely understood.
|Title of host publication||Drug Targeting Technology|
|Subtitle of host publication||Physical Chemical Biological Methods|
|Place of Publication||Boca Raton FL USA|
|Number of pages||46|
|Publication status||Published - 2001|
|Name||Drugs and the pharmaceutical sciences: A Series of Textbooks and Monographs|