Abstract
Recent advances in drug delivery technology have amplified potential opportunities to treat the debilitating diseases that affect the posterior segment of the eye in a less invasive and more efficient manner. Current methods for effective drug delivery to the back of the eye are hindered by many barriers and limitations. As a consequence, considerable efforts have been directed towards developing new materials to selectively deliver drug directly to the target site. This review focuses on lipid-based delivery systems which show promise in improving treatment for the most common disease of the posterior segment of the eye in the developed world, age-related macular degeneration, with an emphasis upon on-demand delivery systems as they have greater potential to overcome the current limitations.
| Original language | English |
|---|---|
| Pages (from-to) | 781-792 |
| Number of pages | 12 |
| Journal | Drug Delivery and Translational Research |
| Volume | 6 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 1 Dec 2016 |
Keywords
- Age-related macular degeneration
- Intravitreal
- Lipids
- Liposomes
- Stimuli responsive
Cite this
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Lipid-based drug delivery systems in the treatment of wet age-related macular degeneration. / Du, Joanne D; Fong, Wye-Khay; Caliph, Suzanne; Boyd, Ben J.
In: Drug Delivery and Translational Research, Vol. 6, No. 6, 01.12.2016, p. 781-792.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - Lipid-based drug delivery systems in the treatment of wet age-related macular degeneration
AU - Du, Joanne D
AU - Fong, Wye-Khay
AU - Caliph, Suzanne
AU - Boyd, Ben J
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Recent advances in drug delivery technology have amplified potential opportunities to treat the debilitating diseases that affect the posterior segment of the eye in a less invasive and more efficient manner. Current methods for effective drug delivery to the back of the eye are hindered by many barriers and limitations. As a consequence, considerable efforts have been directed towards developing new materials to selectively deliver drug directly to the target site. This review focuses on lipid-based delivery systems which show promise in improving treatment for the most common disease of the posterior segment of the eye in the developed world, age-related macular degeneration, with an emphasis upon on-demand delivery systems as they have greater potential to overcome the current limitations.
AB - Recent advances in drug delivery technology have amplified potential opportunities to treat the debilitating diseases that affect the posterior segment of the eye in a less invasive and more efficient manner. Current methods for effective drug delivery to the back of the eye are hindered by many barriers and limitations. As a consequence, considerable efforts have been directed towards developing new materials to selectively deliver drug directly to the target site. This review focuses on lipid-based delivery systems which show promise in improving treatment for the most common disease of the posterior segment of the eye in the developed world, age-related macular degeneration, with an emphasis upon on-demand delivery systems as they have greater potential to overcome the current limitations.
KW - Age-related macular degeneration
KW - Intravitreal
KW - Lipids
KW - Liposomes
KW - Stimuli responsive
UR - http://www.scopus.com/inward/record.url?scp=85014058063&partnerID=8YFLogxK
U2 - 10.1007/s13346-016-0299-6
DO - 10.1007/s13346-016-0299-6
M3 - Review Article
VL - 6
SP - 781
EP - 792
JO - Drug Delivery and Translational Research
JF - Drug Delivery and Translational Research
SN - 2190-393X
IS - 6
ER -