Lipid-based drug delivery systems in the treatment of wet age-related macular degeneration

Joanne D Du, Wye-Khay Fong, Suzanne Caliph, Ben J Boyd

Research output: Contribution to journalReview ArticleResearchpeer-review

7 Citations (Scopus)

Abstract

Recent advances in drug delivery technology have amplified potential opportunities to treat the debilitating diseases that affect the posterior segment of the eye in a less invasive and more efficient manner. Current methods for effective drug delivery to the back of the eye are hindered by many barriers and limitations. As a consequence, considerable efforts have been directed towards developing new materials to selectively deliver drug directly to the target site. This review focuses on lipid-based delivery systems which show promise in improving treatment for the most common disease of the posterior segment of the eye in the developed world, age-related macular degeneration, with an emphasis upon on-demand delivery systems as they have greater potential to overcome the current limitations.

Original languageEnglish
Pages (from-to)781-792
Number of pages12
JournalDrug Delivery and Translational Research
Volume6
Issue number6
DOIs
Publication statusPublished - 1 Dec 2016

Keywords

  • Age-related macular degeneration
  • Intravitreal
  • Lipids
  • Liposomes
  • Stimuli responsive

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