Lipid and small-molecule display by CD1 and MR1

Ildiko Van Rhijn, Dale I Godfrey, Jamie Rossjohn, D Branch Moody

Research output: Contribution to journalArticleResearchpeer-review

73 Citations (Scopus)

Abstract

The antigen-presenting molecules CD1 and MHC class I-related protein (MR1) display lipids and small molecules to T cells. The antigen display platforms in the four CD1 proteins are laterally asymmetrical, so that the T cell receptor (TCR)-binding surfaces are comprised of roofs and portals, rather than the long grooves seen in the MHC antigen-presenting molecules. TCRs can bind CD1 proteins with left-sided or right-sided footprints, creating unexpected modes of antigen recognition. The use of tetramers of human CD1a, CD1b, CD1c or MR1 proteins now allows detailed analysis of the human T cell repertoire, which has revealed new invariant TCRs that bind CD1b molecules and are different from those that define natural killer T cells and mucosal-associated invariant T cells.
Original languageEnglish
Pages (from-to)643 - 654
Number of pages12
JournalNature Reviews Immunology
Volume15
Issue number10
DOIs
Publication statusPublished - 2015

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