Linker chemistry dictates the delivery of a phototoxic organometallic rhenium(i) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles

Sul Hwa Yu, Malay Patra, Stefano Ferrari, Paulina Ramirez Garcia, Nicholas A. Veldhuis, Lisa M. Kaminskas, Bim Graham, John F. Quinn, Michael R. Whittaker, Gilles Gasser, Thomas P. Davis

Research output: Contribution to journalArticleResearchpeer-review

Abstract

We have investigated core-crosslinked star polymer nanoparticles designed with tunable release chemistries as potential nanocarriers for a photoactive Re(i) organometallic complex. The nanoparticles consisted of a brush poly(oligo-ethylene glycol)methyl ether acrylate (POEGA) corona and a cross-linked core of non-biodegradable N,N′-methylenebis(acrylamide) (MBAA) and either pentafluorophenyl acrylate (PFPA), 3-vinyl benzaldehyde (VBA) or diacetone acrylamide (DAAM). Each star was modified with an amine functionalized photodynamic agent (i.e. a rhenium(i) organometallic complex) resulting in the formation of either a stable amide bond (POEGA-star-PFPA), or hydrolytically labile aldimine (POEGA-star-VBA) or ketimine bonds (POEGA-star-DAAM). These materials revealed linker dependent photo- and cytotoxicity when tested in vitro against non-cancerous lung fibroblast MRC-5 cells and HeLa human cervical cancer cells: the toxicity results correlated with final intracellular Re concentrations.

Original languageEnglish
Pages (from-to)7805-7810
Number of pages6
JournalJournal of Materials Chemistry B
Volume6
Issue number47
DOIs
Publication statusPublished - 29 Oct 2018

Cite this

@article{62b38e7c3b964678892c93b80adeeb5d,
title = "Linker chemistry dictates the delivery of a phototoxic organometallic rhenium(i) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles",
abstract = "We have investigated core-crosslinked star polymer nanoparticles designed with tunable release chemistries as potential nanocarriers for a photoactive Re(i) organometallic complex. The nanoparticles consisted of a brush poly(oligo-ethylene glycol)methyl ether acrylate (POEGA) corona and a cross-linked core of non-biodegradable N,N′-methylenebis(acrylamide) (MBAA) and either pentafluorophenyl acrylate (PFPA), 3-vinyl benzaldehyde (VBA) or diacetone acrylamide (DAAM). Each star was modified with an amine functionalized photodynamic agent (i.e. a rhenium(i) organometallic complex) resulting in the formation of either a stable amide bond (POEGA-star-PFPA), or hydrolytically labile aldimine (POEGA-star-VBA) or ketimine bonds (POEGA-star-DAAM). These materials revealed linker dependent photo- and cytotoxicity when tested in vitro against non-cancerous lung fibroblast MRC-5 cells and HeLa human cervical cancer cells: the toxicity results correlated with final intracellular Re concentrations.",
author = "Yu, {Sul Hwa} and Malay Patra and Stefano Ferrari and {Ramirez Garcia}, Paulina and Veldhuis, {Nicholas A.} and Kaminskas, {Lisa M.} and Bim Graham and Quinn, {John F.} and Whittaker, {Michael R.} and Gilles Gasser and Davis, {Thomas P.}",
year = "2018",
month = "10",
day = "29",
doi = "10.1039/c8tb02464b",
language = "English",
volume = "6",
pages = "7805--7810",
journal = "Journal of Materials Chemistry B",
issn = "2050-750X",
publisher = "The Royal Society of Chemistry",
number = "47",

}

Linker chemistry dictates the delivery of a phototoxic organometallic rhenium(i) complex to human cervical cancer cells from core crosslinked star polymer nanoparticles. / Yu, Sul Hwa; Patra, Malay; Ferrari, Stefano; Ramirez Garcia, Paulina; Veldhuis, Nicholas A.; Kaminskas, Lisa M.; Graham, Bim; Quinn, John F.; Whittaker, Michael R.; Gasser, Gilles; Davis, Thomas P.

In: Journal of Materials Chemistry B, Vol. 6, No. 47, 29.10.2018, p. 7805-7810.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Yu, Sul Hwa

AU - Patra, Malay

AU - Ferrari, Stefano

AU - Ramirez Garcia, Paulina

AU - Veldhuis, Nicholas A.

AU - Kaminskas, Lisa M.

AU - Graham, Bim

AU - Quinn, John F.

AU - Whittaker, Michael R.

AU - Gasser, Gilles

AU - Davis, Thomas P.

PY - 2018/10/29

Y1 - 2018/10/29

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