Linkage studies of SOX13, the ICA12 autoantigen gene, in families with type 1 diabetes

Anthony Argentaro, Beth Wapelhorst, Patrick Concannon, Vincent R. Harley

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3 Citations (Scopus)

Abstract

SOX13 is a member of the SOX family of transcription factors that encodes the type 1 diabetes autoantigen, ICA12. The SOX13 gene maps at chromosome 1q31.3-32.1 near a region containing a susceptibility locus for type 1 diabetes. SOX13 was assessed as a candidate susceptibility gene. Analysis of the SOX13 gene identified a number of single nucleotide polymorphisms and a polymorphic CA dinucleotide repeat. Linkage and association studies indiicate that SOX13 is unlikely to make a substantial contribution to type 1 diabetes susceptibility.

Original languageEnglish
Pages (from-to)356-359
Number of pages4
JournalMolecular Genetics and Metabolism
Volume72
Issue number4
DOIs
Publication statusPublished - 1 Jan 2001
Externally publishedYes

Keywords

  • Diabetes
  • HMG box
  • ICA12
  • IDDM
  • Linkage
  • Polymorphisms
  • SOX13
  • SRY

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