LIN-32/Atonal Controls Oxygen Sensing Neuron Development in Caenorhabditis elegans

Teresa Rojo Romanos, David Pladevall-Morera, Kasper Langebeck-Jensen, Stine Hansen, Leelee Ng, Roger Pocock

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Development of complex nervous systems requires precisely controlled neurogenesis. The generation and specification of neurons occur through the transcriptional and post-Transcriptional control of complex regulatory networks. In vertebrates and invertebrates, the proneural basic-helix-loop-helix (bHLH) family of transcription factors has multiple functions in neurogenesis. Here, we identified the LIN-32/Atonal bHLH transcription factor as a key regulator of URXL/R oxygen-sensing neuron development in Caenorhabditis elegans. When LIN-32/Atonal expression is lost, the expression of URX specification and terminal differentiation genes is abrogated. As such, lin-32 mutant animals are unable to respond to increases in environmental oxygen. The URX neurons are generated from a branch of the cell lineage that also produces the CEPDL/R and URADL/R neurons. We found development of these neurons is also defective, suggesting that LIN-32/Atonal regulates neuronal development of the entire lineage. Finally, our results show that aspects of URX neuronal fate are partially restored in lin-32 mutant animals when the apoptosis pathway is inhibited. This suggests that, as in other organisms, LIN-32/Atonal regulates neuronal apoptosis.

Original languageEnglish
Article number7294
Number of pages10
JournalScientific Reports
Volume7
Issue number1
DOIs
Publication statusPublished - 1 Dec 2017

Cite this

Romanos, T. R., Pladevall-Morera, D., Langebeck-Jensen, K., Hansen, S., Ng, L., & Pocock, R. (2017). LIN-32/Atonal Controls Oxygen Sensing Neuron Development in Caenorhabditis elegans. Scientific Reports, 7(1), [7294]. https://doi.org/10.1038/s41598-017-07876-4
Romanos, Teresa Rojo ; Pladevall-Morera, David ; Langebeck-Jensen, Kasper ; Hansen, Stine ; Ng, Leelee ; Pocock, Roger. / LIN-32/Atonal Controls Oxygen Sensing Neuron Development in Caenorhabditis elegans. In: Scientific Reports. 2017 ; Vol. 7, No. 1.
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Romanos, TR, Pladevall-Morera, D, Langebeck-Jensen, K, Hansen, S, Ng, L & Pocock, R 2017, 'LIN-32/Atonal Controls Oxygen Sensing Neuron Development in Caenorhabditis elegans' Scientific Reports, vol. 7, no. 1, 7294. https://doi.org/10.1038/s41598-017-07876-4

LIN-32/Atonal Controls Oxygen Sensing Neuron Development in Caenorhabditis elegans. / Romanos, Teresa Rojo; Pladevall-Morera, David; Langebeck-Jensen, Kasper; Hansen, Stine; Ng, Leelee; Pocock, Roger.

In: Scientific Reports, Vol. 7, No. 1, 7294, 01.12.2017.

Research output: Contribution to journalArticleResearchpeer-review

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