LIM-domain-only proteins in cancer

Jacqueline M Matthews, Krystal Lester, Soumya Joseph, David John Curtis

Research output: Contribution to journalArticleResearchpeer-review

70 Citations (Scopus)

Abstract

LIM-domain proteins are a large family of proteins that are emerging as key molecules in a wide variety of human cancers. In particular, all members of the human LIM-domain-only (LMO) proteins, LMO1-4, which are required for many developmental processes, are implicated in the onset or the progression of several cancers, including T cell leukaemia, breast cancer and neuroblastoma. These small proteins contain two protein-interacting LIM domains but little additional sequence, and they seem to function by nucleating the formation of new transcriptional complexes and/or by disrupting existing transcriptional complexes to modulate gene expression programmes. Through these activities, the LMO proteins have important cellular roles in processes that are relevant to cancer such as self-renewal, cell cycle regulation and metastasis. These functions highlight the therapeutic potential of targeting these proteins in cancer. ? 2013 Macmillan Publishers Limited. All rights reserved.
Original languageEnglish
Pages (from-to)111 - 122
Number of pages12
JournalNature Reviews Cancer
Volume13
Issue number2
DOIs
Publication statusPublished - 2013

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