Light-triggered release of ciprofloxacin from an in situ forming click hydrogel for antibacterial wound dressings

Yue Shi, Vinh X. Truong, Ketav Kulkarni, Yue Qu, George P. Simon, Richard L. Boyd, Patrick Perlmutter, Trevor Lithgow, John S. Forsythe

Research output: Contribution to journalArticleOtherpeer-review

13 Citations (Scopus)

Abstract

Light triggered release of an antibiotic from a click crosslinked hydrogel was developed by conjugating ciprofloxacin through a photo-cleavable linker to the hydrogel network structure. Upon irradiation of the hydrogel material with UV light (365 nm) at low intensity, native ciprofloxacin was released into the surrounding environment and could be detected by HPLC. The antimicrobial activity of the released compound on Staphylococcus aureus was demonstrated.
Original languageEnglish
Pages (from-to)8771 - 8774
Number of pages4
JournalJournal of Materials Chemistry B
Volume3
Issue number45
DOIs
Publication statusPublished - 2015

Cite this

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title = "Light-triggered release of ciprofloxacin from an in situ forming click hydrogel for antibacterial wound dressings",
abstract = "Light triggered release of an antibiotic from a click crosslinked hydrogel was developed by conjugating ciprofloxacin through a photo-cleavable linker to the hydrogel network structure. Upon irradiation of the hydrogel material with UV light (365 nm) at low intensity, native ciprofloxacin was released into the surrounding environment and could be detected by HPLC. The antimicrobial activity of the released compound on Staphylococcus aureus was demonstrated.",
author = "Yue Shi and Truong, {Vinh X.} and Ketav Kulkarni and Yue Qu and Simon, {George P.} and Boyd, {Richard L.} and Patrick Perlmutter and Trevor Lithgow and Forsythe, {John S.}",
year = "2015",
doi = "10.1039/c5tb01820j",
language = "English",
volume = "3",
pages = "8771 -- 8774",
journal = "Journal of Materials Chemistry B",
issn = "2050-750X",
publisher = "The Royal Society of Chemistry",
number = "45",

}

Light-triggered release of ciprofloxacin from an in situ forming click hydrogel for antibacterial wound dressings. / Shi, Yue; Truong, Vinh X.; Kulkarni, Ketav ; Qu, Yue; Simon, George P.; Boyd, Richard L.; Perlmutter, Patrick; Lithgow, Trevor ; Forsythe, John S.

In: Journal of Materials Chemistry B, Vol. 3, No. 45, 2015, p. 8771 - 8774.

Research output: Contribution to journalArticleOtherpeer-review

TY - JOUR

T1 - Light-triggered release of ciprofloxacin from an in situ forming click hydrogel for antibacterial wound dressings

AU - Shi, Yue

AU - Truong, Vinh X.

AU - Kulkarni, Ketav

AU - Qu, Yue

AU - Simon, George P.

AU - Boyd, Richard L.

AU - Perlmutter, Patrick

AU - Lithgow, Trevor

AU - Forsythe, John S.

PY - 2015

Y1 - 2015

N2 - Light triggered release of an antibiotic from a click crosslinked hydrogel was developed by conjugating ciprofloxacin through a photo-cleavable linker to the hydrogel network structure. Upon irradiation of the hydrogel material with UV light (365 nm) at low intensity, native ciprofloxacin was released into the surrounding environment and could be detected by HPLC. The antimicrobial activity of the released compound on Staphylococcus aureus was demonstrated.

AB - Light triggered release of an antibiotic from a click crosslinked hydrogel was developed by conjugating ciprofloxacin through a photo-cleavable linker to the hydrogel network structure. Upon irradiation of the hydrogel material with UV light (365 nm) at low intensity, native ciprofloxacin was released into the surrounding environment and could be detected by HPLC. The antimicrobial activity of the released compound on Staphylococcus aureus was demonstrated.

U2 - 10.1039/c5tb01820j

DO - 10.1039/c5tb01820j

M3 - Article

VL - 3

SP - 8771

EP - 8774

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

SN - 2050-750X

IS - 45

ER -