Light-triggered release of ciprofloxacin from an in situ forming click hydrogel for antibacterial wound dressings

Yue Shi; Vinh X. Truong; Ketav  Kulkarni; Yue Qu; George P. Simon; Richard L. Boyd; Patrick Perlmutter; Trevor  Lithgow; John S. Forsythe

doi:10.1039/c5tb01820j

Light-triggered release of ciprofloxacin from an in situ forming click hydrogel for antibacterial wound dressings

Yue Shi, Vinh X. Truong, Ketav Kulkarni, Yue Qu, George P. Simon, Richard L. Boyd, Patrick Perlmutter, Trevor Lithgow, John S. Forsythe

Research output: Contribution to journal › Article › Other › peer-review

49 Citations (Scopus)

Abstract

Light triggered release of an antibiotic from a click crosslinked hydrogel was developed by conjugating ciprofloxacin through a photo-cleavable linker to the hydrogel network structure. Upon irradiation of the hydrogel material with UV light (365 nm) at low intensity, native ciprofloxacin was released into the surrounding environment and could be detected by HPLC. The antimicrobial activity of the released compound on Staphylococcus aureus was demonstrated.

Original language	English
Pages (from-to)	8771 - 8774
Number of pages	4
Journal	Journal of Materials Chemistry B
Volume	3
Issue number	45
DOIs	https://doi.org/10.1039/c5tb01820j
Publication status	Published - 2015

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10.1039/c5tb01820j

Molecular Machines and Bacterial Cell Biology.
Lithgow, T.
Australian Research Council (ARC)
31/12/13 → 16/07/19
Project: Research
Fighting infection: exploiting host-pathogen interactions
Lithgow, T., Hartland, E. L., Stow, J., Strugnell, R. A. & Teasdale, R. D.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/11 → 31/12/15
Project: Research

Cite this

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title = "Light-triggered release of ciprofloxacin from an in situ forming click hydrogel for antibacterial wound dressings",

abstract = "Light triggered release of an antibiotic from a click crosslinked hydrogel was developed by conjugating ciprofloxacin through a photo-cleavable linker to the hydrogel network structure. Upon irradiation of the hydrogel material with UV light (365 nm) at low intensity, native ciprofloxacin was released into the surrounding environment and could be detected by HPLC. The antimicrobial activity of the released compound on Staphylococcus aureus was demonstrated.",

author = "Yue Shi and Truong, {Vinh X.} and Ketav Kulkarni and Yue Qu and Simon, {George P.} and Boyd, {Richard L.} and Patrick Perlmutter and Trevor Lithgow and Forsythe, {John S.}",

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AU - Shi, Yue

AU - Truong, Vinh X.

AU - Kulkarni, Ketav

AU - Qu, Yue

AU - Simon, George P.

AU - Boyd, Richard L.

AU - Perlmutter, Patrick

AU - Lithgow, Trevor

AU - Forsythe, John S.

PY - 2015

Y1 - 2015

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AB - Light triggered release of an antibiotic from a click crosslinked hydrogel was developed by conjugating ciprofloxacin through a photo-cleavable linker to the hydrogel network structure. Upon irradiation of the hydrogel material with UV light (365 nm) at low intensity, native ciprofloxacin was released into the surrounding environment and could be detected by HPLC. The antimicrobial activity of the released compound on Staphylococcus aureus was demonstrated.

U2 - 10.1039/c5tb01820j

DO - 10.1039/c5tb01820j

M3 - Article

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EP - 8774

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 45

ER -

Light-triggered release of ciprofloxacin from an in situ forming click hydrogel for antibacterial wound dressings

Abstract

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Projects

Molecular Machines and Bacterial Cell Biology.

Fighting infection: exploiting host-pathogen interactions

Cite this