Light-triggered release of ciprofloxacin from an in situ forming click hydrogel for antibacterial wound dressings

Yue Shi, Vinh X. Truong, Ketav Kulkarni, Yue Qu, George P. Simon, Richard L. Boyd, Patrick Perlmutter, Trevor Lithgow, John S. Forsythe

Research output: Contribution to journalArticleOtherpeer-review

21 Citations (Scopus)

Abstract

Light triggered release of an antibiotic from a click crosslinked hydrogel was developed by conjugating ciprofloxacin through a photo-cleavable linker to the hydrogel network structure. Upon irradiation of the hydrogel material with UV light (365 nm) at low intensity, native ciprofloxacin was released into the surrounding environment and could be detected by HPLC. The antimicrobial activity of the released compound on Staphylococcus aureus was demonstrated.
Original languageEnglish
Pages (from-to)8771 - 8774
Number of pages4
JournalJournal of Materials Chemistry B
Volume3
Issue number45
DOIs
Publication statusPublished - 2015

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