Abstract
The miniaturization of Light-Sheet Fluorescence Microcopy and its integration with a microfluidic system for sample delivery and control is demonstrated in this abstract. A micro-optical system has been designed and fabricated to generate 1 µm thickness light-sheets using air-cavities on PDMS as cylindrical micro-lenses. The material of these micro-lenses eases the coupling to microfluidic devices as they can be monolithically fabricated together. This device enables the high-throughput 3D imaging of single live cells with sub-cellular resolution. This new technology has the potential to change how we image suspension cells and in the future can be easily adopted by many cell biologists.
| Original language | English |
|---|---|
| Title of host publication | MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 809-810 |
| Number of pages | 2 |
| ISBN (Electronic) | 9781733419017 |
| Publication status | Published - 2020 |
| Event | International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2020) - Virtual, United States of America Duration: 4 Oct 2020 → 9 Oct 2020 Conference number: 24th https://microtas2020.org (Website) https://pubs.acs.org/toc/aamick/10/48?ref=breadcrumb (Proceedings) |
Conference
| Conference | International Conference on Miniaturized Systems for Chemistry and Life Sciences (MicroTAS 2020) |
|---|---|
| Abbreviated title | MicroTAS 2020 |
| Country/Territory | United States of America |
| Period | 4/10/20 → 9/10/20 |
| Internet address |
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Keywords
- Flow cytometry
- Light-Sheet Fluorescence Microscopy on a Chip
- Single cell 3D analysis
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