Ligand-induced dimer-tetramer transition during the activation of the cell surface epidermal growth factor receptor-A multidimensional microscopy analysis

Andrew H A Clayton, Francesca Walker, Suzanne G Orchard, Christine Henderson, Dominik Fuchs, Julie Rothacker, Edouard C Nice, Anthony W Burgess

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192 Citations (Scopus)

Abstract

The epidermal growth factor receptor (EGFR) is a member of the erbB tyrosine kinase family of receptors. For many years it has been believed that receptor activation occurs via a monomer-dimer transition that is associated with a conformational change to activate the kinase. However, little is known about the quaternary state of the receptor at normal levels of expression (
Original languageEnglish
Pages (from-to)30392 - 30399
Number of pages8
JournalJournal of Biological Chemistry
Volume280
Issue number34
Publication statusPublished - 2005
Externally publishedYes

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