Ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy: an unprecedented access to 1-thienyl pyrroloquinoxalines for the new approach towards apoptosis

Sunder Kumar Kolli; Ali Nakhi; Sivakumar Archana; Maneesha Saridena; Girdhar Singh Deora; Swapna Yellanki; Raghavender Medisetti; Pushkar Kulkarni; R. Ramesh Raju; Manojit Pal

doi:10.1016/j.ejmech.2014.08.057

Ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy: an unprecedented access to 1-thienyl pyrroloquinoxalines for the new approach towards apoptosis

Sunder Kumar Kolli, Ali Nakhi, Sivakumar Archana, Maneesha Saridena, Girdhar Singh Deora, Swapna Yellanki, Raghavender Medisetti, Pushkar Kulkarni, R. Ramesh Raju, Manojit Pal

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

Abstract

The link between PDE4 and apoptosis prompted us to design and synthesize for the first time a series of novel 1-thienyl pyrroloquinoxalines as potential PDE4 inhibitors/apoptotic agents. A ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy has been developed for the rapid and milder access to this class of compounds some of which showed interesting pharmacological properties when tested in vitro and in zebrafish embryos.

Original language	English
Pages (from-to)	270-278
Number of pages	9
Journal	European Journal of Medicinal Chemistry
Volume	86
DOIs	https://doi.org/10.1016/j.ejmech.2014.08.057
Publication status	Published - 30 Oct 2014
Externally published	Yes

Keywords

Apoptosis
Palladium
PDE4
Pyrroloquinoxaline
Zebrafish

Access to Document

10.1016/j.ejmech.2014.08.057

Cite this

Kolli, S. K., Nakhi, A., Archana, S., Saridena, M., Deora, G. S., Yellanki, S., Medisetti, R., Kulkarni, P., Ramesh Raju, R., & Pal, M. (2014). Ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy: an unprecedented access to 1-thienyl pyrroloquinoxalines for the new approach towards apoptosis. European Journal of Medicinal Chemistry, 86, 270-278. https://doi.org/10.1016/j.ejmech.2014.08.057

@article{6c3c3e20fe4042269c397778fe51f0f0,

title = "Ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy: an unprecedented access to 1-thienyl pyrroloquinoxalines for the new approach towards apoptosis",

abstract = "The link between PDE4 and apoptosis prompted us to design and synthesize for the first time a series of novel 1-thienyl pyrroloquinoxalines as potential PDE4 inhibitors/apoptotic agents. A ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy has been developed for the rapid and milder access to this class of compounds some of which showed interesting pharmacological properties when tested in vitro and in zebrafish embryos.",

keywords = "Apoptosis, Palladium, PDE4, Pyrroloquinoxaline, Zebrafish",

author = "Kolli, {Sunder Kumar} and Ali Nakhi and Sivakumar Archana and Maneesha Saridena and Deora, {Girdhar Singh} and Swapna Yellanki and Raghavender Medisetti and Pushkar Kulkarni and {Ramesh Raju}, R. and Manojit Pal",

year = "2014",

month = oct,

day = "30",

doi = "10.1016/j.ejmech.2014.08.057",

language = "English",

volume = "86",

pages = "270--278",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

publisher = "Elsevier",

}

Kolli, SK, Nakhi, A, Archana, S, Saridena, M, Deora, GS, Yellanki, S, Medisetti, R, Kulkarni, P, Ramesh Raju, R & Pal, M 2014, 'Ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy: an unprecedented access to 1-thienyl pyrroloquinoxalines for the new approach towards apoptosis', European Journal of Medicinal Chemistry, vol. 86, pp. 270-278. https://doi.org/10.1016/j.ejmech.2014.08.057

Ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy: an unprecedented access to 1-thienyl pyrroloquinoxalines for the new approach towards apoptosis. / Kolli, Sunder Kumar; Nakhi, Ali; Archana, Sivakumar et al.
In: European Journal of Medicinal Chemistry, Vol. 86, 30.10.2014, p. 270-278.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy

T2 - an unprecedented access to 1-thienyl pyrroloquinoxalines for the new approach towards apoptosis

AU - Kolli, Sunder Kumar

AU - Nakhi, Ali

AU - Archana, Sivakumar

AU - Saridena, Maneesha

AU - Deora, Girdhar Singh

AU - Yellanki, Swapna

AU - Medisetti, Raghavender

AU - Kulkarni, Pushkar

AU - Ramesh Raju, R.

AU - Pal, Manojit

PY - 2014/10/30

Y1 - 2014/10/30

N2 - The link between PDE4 and apoptosis prompted us to design and synthesize for the first time a series of novel 1-thienyl pyrroloquinoxalines as potential PDE4 inhibitors/apoptotic agents. A ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy has been developed for the rapid and milder access to this class of compounds some of which showed interesting pharmacological properties when tested in vitro and in zebrafish embryos.

AB - The link between PDE4 and apoptosis prompted us to design and synthesize for the first time a series of novel 1-thienyl pyrroloquinoxalines as potential PDE4 inhibitors/apoptotic agents. A ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy has been developed for the rapid and milder access to this class of compounds some of which showed interesting pharmacological properties when tested in vitro and in zebrafish embryos.

KW - Apoptosis

KW - Palladium

KW - PDE4

KW - Pyrroloquinoxaline

KW - Zebrafish

UR - http://www.scopus.com/inward/record.url?scp=84906778016&partnerID=8YFLogxK

U2 - 10.1016/j.ejmech.2014.08.057

DO - 10.1016/j.ejmech.2014.08.057

M3 - Article

C2 - 25171781

AN - SCOPUS:84906778016

SN - 0223-5234

VL - 86

SP - 270

EP - 278

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

ER -

Ligand-free Pd-catalyzed C-N cross-coupling/cyclization strategy: an unprecedented access to 1-thienyl pyrroloquinoxalines for the new approach towards apoptosis

Abstract

Keywords

Access to Document

Other files and links

Cite this