A synthetic method to prepare tricyclic bridged heptenones and hexenones from gold(I)-catalyzed double cycloisomerization of 1,11-dien-3,9-diyne benzoates is described. A divergence in product selectivity was achieved by fine-tuning the steric nature of the ligand of the Au(I) catalyst. In the presence of [MeCNAu(JohnPhos)]+SbF6- (JohnPhos = (1,1?-biphenyl-2-yl)-di-tert-butylphosphine) as the catalyst, tandem 1,3-acyloxy migration/metallo-Nazarov cyclization/1,6-enyne addition/Cope rearrangement of the substrate was found to selectively occur to afford the bridged heptenone adduct. In contrast, changing the Au(I) catalyst to [MeCNAu(Me4tBuXPhos)]+SbF6- (Me4tBuXPhos = di-tert-butyl(2?,4?,6?-triisopropyl-3,4,5,6-tetramethyl-[1,1?-biphenyl]-2-yl)phosphine) was observed to result in the 1,11-dien-3,9-diyne benzoate undergoing a more rapid tandem 1,3-acyloxy migration/metallo-Nazarov cyclization/[4 + 2]-cyclization pathway to give the bridged hexenone derivative.
Rao, W., Susanti, D., Ayers, B. J., & Chan, P. W. H. (2015). Ligand-controlled product selectivity in gold-catalyzed double cycloisomerization of 1,11-dien-3,9-diyne benzoates. Journal of the American Chemical Society, 137(19), 6350-6355. https://doi.org/10.1021/jacs.5b02377