Lifestyle and pregnancy complications in polycystic ovary syndrome

The SCOPE cohort study

Mahnaz Bahri Khomami, Lisa J. Moran, Louise Kenny, Jessica A. Grieger, Jenny Myers, Lucilla Poston, Lesley McCowan, James Walker, Gustaaf Dekker, Robert Norman, Claire T. Roberts

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Objectives: To investigate the risk of pregnancy complications in women with and without polycystic ovary syndrome after consideration of lifestyle factors. Design: Prospective cohort. Patients and measurements: Participants (n = 5628) were apparently healthy nulliparous women with singleton pregnancies from the Screening for Pregnancy Endpoints study in New Zealand, Australia, United Kingdom and Ireland. Multivariable regression models were performed assessing the association of self-reported polycystic ovary syndrome status with pregnancy complications with consideration of lifestyle factors at the 15th week of gestation. Results: Women with polycystic ovary syndrome (n = 354) were older, had a higher socio-economic index and body mass index and were less likely to consume alcohol and smoke but more likely to do vigorous exercise and take multivitamins. In univariable analysis, polycystic ovary syndrome was associated with increased risk of gestational diabetes (OR: 2.2, 95% CI: 1.2, 4.0). In multivariable models, polycystic ovary syndrome was only significantly associated with decreased risk of large for gestational age (OR: 0.62, 95% CI: 0.40, 0.98) with a population attributable risk of 0.22%. None of the other outcomes were attributable to polycystic ovary syndrome status. Conclusions: Polycystic ovary syndrome is associated with a lower risk of large for gestational age infants. In this low-risk population, the risk of pregnancy complications was not increased in women with polycystic ovary syndrome who were following a healthy lifestyle. Further studies are warranted assessing the contribution of lifestyle factors to the risk of pregnancy complications in higher risk groups of women with and without polycystic ovary syndrome.

Original languageEnglish
Pages (from-to)814-821
Number of pages8
JournalClinical Endocrinology
Volume90
Issue number6
DOIs
Publication statusPublished - Jun 2019

Keywords

  • birthweight
  • gestational diabetes
  • gestational hypertension
  • large for gestational age
  • lifestyle
  • polycystic ovary syndrome
  • preterm birth

Cite this

Bahri Khomami, M., Moran, L. J., Kenny, L., Grieger, J. A., Myers, J., Poston, L., ... Roberts, C. T. (2019). Lifestyle and pregnancy complications in polycystic ovary syndrome: The SCOPE cohort study. Clinical Endocrinology, 90(6), 814-821. https://doi.org/10.1111/cen.13954
Bahri Khomami, Mahnaz ; Moran, Lisa J. ; Kenny, Louise ; Grieger, Jessica A. ; Myers, Jenny ; Poston, Lucilla ; McCowan, Lesley ; Walker, James ; Dekker, Gustaaf ; Norman, Robert ; Roberts, Claire T. / Lifestyle and pregnancy complications in polycystic ovary syndrome : The SCOPE cohort study. In: Clinical Endocrinology. 2019 ; Vol. 90, No. 6. pp. 814-821.
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title = "Lifestyle and pregnancy complications in polycystic ovary syndrome: The SCOPE cohort study",
abstract = "Objectives: To investigate the risk of pregnancy complications in women with and without polycystic ovary syndrome after consideration of lifestyle factors. Design: Prospective cohort. Patients and measurements: Participants (n = 5628) were apparently healthy nulliparous women with singleton pregnancies from the Screening for Pregnancy Endpoints study in New Zealand, Australia, United Kingdom and Ireland. Multivariable regression models were performed assessing the association of self-reported polycystic ovary syndrome status with pregnancy complications with consideration of lifestyle factors at the 15th week of gestation. Results: Women with polycystic ovary syndrome (n = 354) were older, had a higher socio-economic index and body mass index and were less likely to consume alcohol and smoke but more likely to do vigorous exercise and take multivitamins. In univariable analysis, polycystic ovary syndrome was associated with increased risk of gestational diabetes (OR: 2.2, 95{\%} CI: 1.2, 4.0). In multivariable models, polycystic ovary syndrome was only significantly associated with decreased risk of large for gestational age (OR: 0.62, 95{\%} CI: 0.40, 0.98) with a population attributable risk of 0.22{\%}. None of the other outcomes were attributable to polycystic ovary syndrome status. Conclusions: Polycystic ovary syndrome is associated with a lower risk of large for gestational age infants. In this low-risk population, the risk of pregnancy complications was not increased in women with polycystic ovary syndrome who were following a healthy lifestyle. Further studies are warranted assessing the contribution of lifestyle factors to the risk of pregnancy complications in higher risk groups of women with and without polycystic ovary syndrome.",
keywords = "birthweight, gestational diabetes, gestational hypertension, large for gestational age, lifestyle, polycystic ovary syndrome, preterm birth",
author = "{Bahri Khomami}, Mahnaz and Moran, {Lisa J.} and Louise Kenny and Grieger, {Jessica A.} and Jenny Myers and Lucilla Poston and Lesley McCowan and James Walker and Gustaaf Dekker and Robert Norman and Roberts, {Claire T.}",
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Bahri Khomami, M, Moran, LJ, Kenny, L, Grieger, JA, Myers, J, Poston, L, McCowan, L, Walker, J, Dekker, G, Norman, R & Roberts, CT 2019, 'Lifestyle and pregnancy complications in polycystic ovary syndrome: The SCOPE cohort study', Clinical Endocrinology, vol. 90, no. 6, pp. 814-821. https://doi.org/10.1111/cen.13954

Lifestyle and pregnancy complications in polycystic ovary syndrome : The SCOPE cohort study. / Bahri Khomami, Mahnaz; Moran, Lisa J.; Kenny, Louise; Grieger, Jessica A.; Myers, Jenny; Poston, Lucilla; McCowan, Lesley; Walker, James; Dekker, Gustaaf; Norman, Robert; Roberts, Claire T.

In: Clinical Endocrinology, Vol. 90, No. 6, 06.2019, p. 814-821.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Lifestyle and pregnancy complications in polycystic ovary syndrome

T2 - The SCOPE cohort study

AU - Bahri Khomami, Mahnaz

AU - Moran, Lisa J.

AU - Kenny, Louise

AU - Grieger, Jessica A.

AU - Myers, Jenny

AU - Poston, Lucilla

AU - McCowan, Lesley

AU - Walker, James

AU - Dekker, Gustaaf

AU - Norman, Robert

AU - Roberts, Claire T.

PY - 2019/6

Y1 - 2019/6

N2 - Objectives: To investigate the risk of pregnancy complications in women with and without polycystic ovary syndrome after consideration of lifestyle factors. Design: Prospective cohort. Patients and measurements: Participants (n = 5628) were apparently healthy nulliparous women with singleton pregnancies from the Screening for Pregnancy Endpoints study in New Zealand, Australia, United Kingdom and Ireland. Multivariable regression models were performed assessing the association of self-reported polycystic ovary syndrome status with pregnancy complications with consideration of lifestyle factors at the 15th week of gestation. Results: Women with polycystic ovary syndrome (n = 354) were older, had a higher socio-economic index and body mass index and were less likely to consume alcohol and smoke but more likely to do vigorous exercise and take multivitamins. In univariable analysis, polycystic ovary syndrome was associated with increased risk of gestational diabetes (OR: 2.2, 95% CI: 1.2, 4.0). In multivariable models, polycystic ovary syndrome was only significantly associated with decreased risk of large for gestational age (OR: 0.62, 95% CI: 0.40, 0.98) with a population attributable risk of 0.22%. None of the other outcomes were attributable to polycystic ovary syndrome status. Conclusions: Polycystic ovary syndrome is associated with a lower risk of large for gestational age infants. In this low-risk population, the risk of pregnancy complications was not increased in women with polycystic ovary syndrome who were following a healthy lifestyle. Further studies are warranted assessing the contribution of lifestyle factors to the risk of pregnancy complications in higher risk groups of women with and without polycystic ovary syndrome.

AB - Objectives: To investigate the risk of pregnancy complications in women with and without polycystic ovary syndrome after consideration of lifestyle factors. Design: Prospective cohort. Patients and measurements: Participants (n = 5628) were apparently healthy nulliparous women with singleton pregnancies from the Screening for Pregnancy Endpoints study in New Zealand, Australia, United Kingdom and Ireland. Multivariable regression models were performed assessing the association of self-reported polycystic ovary syndrome status with pregnancy complications with consideration of lifestyle factors at the 15th week of gestation. Results: Women with polycystic ovary syndrome (n = 354) were older, had a higher socio-economic index and body mass index and were less likely to consume alcohol and smoke but more likely to do vigorous exercise and take multivitamins. In univariable analysis, polycystic ovary syndrome was associated with increased risk of gestational diabetes (OR: 2.2, 95% CI: 1.2, 4.0). In multivariable models, polycystic ovary syndrome was only significantly associated with decreased risk of large for gestational age (OR: 0.62, 95% CI: 0.40, 0.98) with a population attributable risk of 0.22%. None of the other outcomes were attributable to polycystic ovary syndrome status. Conclusions: Polycystic ovary syndrome is associated with a lower risk of large for gestational age infants. In this low-risk population, the risk of pregnancy complications was not increased in women with polycystic ovary syndrome who were following a healthy lifestyle. Further studies are warranted assessing the contribution of lifestyle factors to the risk of pregnancy complications in higher risk groups of women with and without polycystic ovary syndrome.

KW - birthweight

KW - gestational diabetes

KW - gestational hypertension

KW - large for gestational age

KW - lifestyle

KW - polycystic ovary syndrome

KW - preterm birth

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SP - 814

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JO - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

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