Lgl, the SWH pathway and tumorigenesis: It's a matter of context & competition!

Nicola A. Grzeschik, Linda M. Parsons, Helena Elizabeth Richardson

Research output: Contribution to journalReview ArticleResearchpeer-review

35 Citations (Scopus)


Loss of function of the neoplastic tumors suppressors, lgl, scrib and dlg or overexpression of the apical polarity components, Crumbs and atypical protein kinase C (aPKC), are associated with polarity loss and tissue overgrowth, however, the mechanism behind these effects is poorly understood. In our recent study, we showed that Lgl, aPKC and Crumbs mediate their effects on proliferation and survival via the Salvador/Warts/Hippo (SWH) tumor suppressor pathway. Loss of lgl can lead to substantial overgrowth, however the lgl mutant phenotype can be quite variable and the amount of overgrowth of the mutant tissue, its survival and ultimate fate is strongly determined by context and competition. In this extra-view we present a more detailed description of the lgl mutant phenotype and highlight the phenotypic differences between lgl and SWH pathway mutant phenotypes. In addition, we explore the role for the Jun kinase (JNK) pathway in the development of the lgl mutant phenotype.

Original languageEnglish
Pages (from-to)3202-3212
Number of pages11
JournalCell Cycle
Issue number16
Publication statusPublished - 15 Aug 2010
Externally publishedYes


  • aPKC
  • Cell competition
  • crb
  • dlg
  • Epithelial polarity
  • JNK pathway
  • lgl
  • Neoplastic tumor suppressors
  • Scrib
  • SWH pathway

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