Lewy- and Alzheimer-type pathologies in Parkinson's disease dementia: which is more important?

Yaroslau Compta, Laura Parkkinen, Sean O'Sullivan, Jana Vandrovcova, Janice Holton, Catherine Collins, Tammaryn Lashley, Constantinos Kallis, David Williams, Rohan de Silva, Andrew Lees, Tamas Revesz

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322 Citations (Scopus)

Abstract

The relative importance of Lewy- and Alzheimer-type pathologies to dementia in Parkinson s disease remains unclear. We have examined the combined associations of a-synuclein, tau and amyloid-b accumulation in 56 pathologically confirmed Parkinson s disease cases, 29 of whom had developed dementia. Cortical and subcortical amyloid-b scores were obtained, while tau and a-synuclein pathologies were rated according to the respective Braak stages. Additionally, cortical Lewy body and Lewy neurite scores were determined and Lewy body densities were generated using morphometry. Non-parametric statistics, together with regression models, receiver-operating characteristic curves and survival analyses were applied
Original languageEnglish
Pages (from-to)1493 - 1505
Number of pages13
JournalBrain
Volume134
Issue number5
DOIs
Publication statusPublished - 2011

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