Levosimendan infusion improves cardiac output but not blood pressure in a rodent model of severe metoprolol toxicity

Yasmean Kalam; Andis Graudins

doi:10.1177/0960327111433182

Levosimendan infusion improves cardiac output but not blood pressure in a rodent model of severe metoprolol toxicity

Yasmean Kalam, Andis Graudins

Medicine Monash Health

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

Levosimendan (Levo) is an inodilator improving cardiac output (CO) and reducing afterload in heart failure. Previously, we reported that Levo improved CO but not blood pressure (BP) in a rodent model of verapamil poisoning. We theorised that Levo-induced vasodilation should not influence BP to a similar degree in metoprolol poisoning.

Original language	English
Pages (from-to)	955 - 963
Number of pages	9
Journal	Human and Experimental Toxicology
Volume	31
Issue number	9
DOIs	https://doi.org/10.1177/0960327111433182
Publication status	Published - 2012

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Cite this

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title = "Levosimendan infusion improves cardiac output but not blood pressure in a rodent model of severe metoprolol toxicity",

abstract = "Levosimendan (Levo) is an inodilator improving cardiac output (CO) and reducing afterload in heart failure. Previously, we reported that Levo improved CO but not blood pressure (BP) in a rodent model of verapamil poisoning. We theorised that Levo-induced vasodilation should not influence BP to a similar degree in metoprolol poisoning.",

author = "Yasmean Kalam and Andis Graudins",

year = "2012",

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T1 - Levosimendan infusion improves cardiac output but not blood pressure in a rodent model of severe metoprolol toxicity

AU - Kalam, Yasmean

AU - Graudins, Andis

PY - 2012

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N2 - Levosimendan (Levo) is an inodilator improving cardiac output (CO) and reducing afterload in heart failure. Previously, we reported that Levo improved CO but not blood pressure (BP) in a rodent model of verapamil poisoning. We theorised that Levo-induced vasodilation should not influence BP to a similar degree in metoprolol poisoning.

AB - Levosimendan (Levo) is an inodilator improving cardiac output (CO) and reducing afterload in heart failure. Previously, we reported that Levo improved CO but not blood pressure (BP) in a rodent model of verapamil poisoning. We theorised that Levo-induced vasodilation should not influence BP to a similar degree in metoprolol poisoning.

UR - http://www.ncbi.nlm.nih.gov/pubmed/22249394

U2 - 10.1177/0960327111433182

DO - 10.1177/0960327111433182

M3 - Article

VL - 31

SP - 955

EP - 963

JO - Human and Experimental Toxicology

JF - Human and Experimental Toxicology

SN - 0960-3271

IS - 9

ER -