Leukocyte-stromal interactions within lymph nodes

Joshua D’Rozario, David Roberts, Muath Suliman, Konstantin Knoblich, Anne Fletcher

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

Abstract

Lymph nodes play a crucial role in the formation and initiation of immune responses, allowing lymphocytes to efficiently scan for foreign antigens and serving as rendezvous points for leukocyte-antigen interactions. Here we describe the major stromal subsets found in lymph nodes, including fibroblastic reticular cells, lymphatic endothelial cells, blood endothelial cells, marginal reticular cells, follicular dendritic cells and other poorly defined subsets such as integrin alpha-7+ pericytes. We focus on biomedically relevant interactions with T cells, B cells and dendritic cells, describing pro-survival mechanisms of support for these cells, promotion of their migration and tolerance-inducing mechanisms that help keep the body free of autoimmune-mediated damage.

Original languageEnglish
Title of host publicationStromal Immunology
EditorsBenjamin M.J. Owens, Matthew A. Lakins
PublisherSpringer
Chapter1
Number of pages22
ISBN (Electronic)9783319781273
ISBN (Print)9783319781259
DOIs
Publication statusPublished - 1 Jan 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1060
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Endothelial cells
  • Fibroblasts
  • FRCs
  • LECs
  • Lymph nodes
  • Lymphatic endothelium
  • Lymphoid fibroblasts
  • Non-haematopoietic
  • Podoplanin
  • Stromal cells
  • Stromal Immunology

Cite this

D’Rozario, J., Roberts, D., Suliman, M., Knoblich, K., & Fletcher, A. (2018). Leukocyte-stromal interactions within lymph nodes. In B. M. J. Owens, & M. A. Lakins (Eds.), Stromal Immunology (Advances in Experimental Medicine and Biology; Vol. 1060). Springer. https://doi.org/10.1007/978-3-319-78127-3_1
D’Rozario, Joshua ; Roberts, David ; Suliman, Muath ; Knoblich, Konstantin ; Fletcher, Anne. / Leukocyte-stromal interactions within lymph nodes. Stromal Immunology. editor / Benjamin M.J. Owens ; Matthew A. Lakins. Springer, 2018. (Advances in Experimental Medicine and Biology).
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D’Rozario, J, Roberts, D, Suliman, M, Knoblich, K & Fletcher, A 2018, Leukocyte-stromal interactions within lymph nodes. in BMJ Owens & MA Lakins (eds), Stromal Immunology. Advances in Experimental Medicine and Biology, vol. 1060, Springer. https://doi.org/10.1007/978-3-319-78127-3_1

Leukocyte-stromal interactions within lymph nodes. / D’Rozario, Joshua; Roberts, David; Suliman, Muath; Knoblich, Konstantin; Fletcher, Anne.

Stromal Immunology. ed. / Benjamin M.J. Owens; Matthew A. Lakins. Springer, 2018. (Advances in Experimental Medicine and Biology; Vol. 1060).

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

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D’Rozario J, Roberts D, Suliman M, Knoblich K, Fletcher A. Leukocyte-stromal interactions within lymph nodes. In Owens BMJ, Lakins MA, editors, Stromal Immunology. Springer. 2018. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-3-319-78127-3_1