Leukemia inhibitory factor by systemic administration rescues spinal motor neurons in the SOD1 G93A murine model of familial amyotrophic lateral sclerosis

Michael F. Azari, Adam Galle, Elizabeth C. Lopes, John Kurek, Surindar S. Cheema

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31 Citations (Scopus)

Abstract

Leukemia inhibitory factor (LIF) is a survival factor for motoneurons. In this study we investigated whether intense systemic LIF therapy prevents the loss of lumbar motoneurons in the transgenic SOD1 G93A mouse model of familial amyotrophic lateral sclerosis. Treatment involved daily 25 μg/kg intraperitoneal injection for a period of 6 weeks starting at 70 days of age. Using the unbiased optical dissector technique, significant rescue of motoneurons in the LIF-treated group (3809±455) was found compared to the vehicle group (1085±140).

Original languageEnglish
Pages (from-to)144-147
Number of pages4
JournalBrain Research
Volume922
Issue number1
DOIs
Publication statusPublished - 13 Dec 2001

Keywords

  • Leukemia inhibitory
  • Neuroprotective
  • SOD1 G93A transgenic mice
  • Spinal motonueron

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