Leukemia inhibitory factor and interleukin-11: Critical regulators in the establishment of pregnancy

Premila Paiva, Ellen Menkhorst, Lois Salamonsen, Evdokia Dimitriadis

Research output: Contribution to journalReview ArticleResearchpeer-review

73 Citations (Scopus)

Abstract

Blastocyst implantation into a receptive endometrium is critical to the establishment of pregnancy and is tightly regulated by factors within the blastocyst-endometrial micro-environment. Leukemia inhibitory factor (LIF) and interleukin-11 (IL11) have key roles during implantation. Female mice with a null mutation in the LIF or IL11RA gene are infertile due to a complete failure of implantation or a defective differentiation/decidualization response to the implanting blastocyst, respectively. LIF and IL11 deficiency during pregnancy is associated with infertility and miscarriage in women. Numerous cell populations at the maternal-fetal interface are regulated by LIF/IL11 including the endometrial epithelium, decidualizing stroma, placental trophoblasts and leukocytes. This review focuses on the roles of LIF/IL11 during early pregnancy and highlights their potential as contraceptive targets and therapeutic agents for infertility.

Original languageEnglish
Pages (from-to)319-328
Number of pages10
JournalCytokine and Growth Factor Reviews
Volume20
Issue number4
DOIs
Publication statusPublished - Aug 2009

Keywords

  • Cytokine
  • Fertility
  • IL11
  • Implantation
  • LIF

Cite this

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abstract = "Blastocyst implantation into a receptive endometrium is critical to the establishment of pregnancy and is tightly regulated by factors within the blastocyst-endometrial micro-environment. Leukemia inhibitory factor (LIF) and interleukin-11 (IL11) have key roles during implantation. Female mice with a null mutation in the LIF or IL11RA gene are infertile due to a complete failure of implantation or a defective differentiation/decidualization response to the implanting blastocyst, respectively. LIF and IL11 deficiency during pregnancy is associated with infertility and miscarriage in women. Numerous cell populations at the maternal-fetal interface are regulated by LIF/IL11 including the endometrial epithelium, decidualizing stroma, placental trophoblasts and leukocytes. This review focuses on the roles of LIF/IL11 during early pregnancy and highlights their potential as contraceptive targets and therapeutic agents for infertility.",
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Leukemia inhibitory factor and interleukin-11 : Critical regulators in the establishment of pregnancy. / Paiva, Premila; Menkhorst, Ellen; Salamonsen, Lois; Dimitriadis, Evdokia.

In: Cytokine and Growth Factor Reviews, Vol. 20, No. 4, 08.2009, p. 319-328.

Research output: Contribution to journalReview ArticleResearchpeer-review

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T2 - Critical regulators in the establishment of pregnancy

AU - Paiva, Premila

AU - Menkhorst, Ellen

AU - Salamonsen, Lois

AU - Dimitriadis, Evdokia

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