TY - JOUR
T1 - Leukemia inhibitory factor and interleukin-11
T2 - Critical regulators in the establishment of pregnancy
AU - Paiva, Premila
AU - Menkhorst, Ellen
AU - Salamonsen, Lois
AU - Dimitriadis, Evdokia
PY - 2009/8
Y1 - 2009/8
N2 - Blastocyst implantation into a receptive endometrium is critical to the establishment of pregnancy and is tightly regulated by factors within the blastocyst-endometrial micro-environment. Leukemia inhibitory factor (LIF) and interleukin-11 (IL11) have key roles during implantation. Female mice with a null mutation in the LIF or IL11RA gene are infertile due to a complete failure of implantation or a defective differentiation/decidualization response to the implanting blastocyst, respectively. LIF and IL11 deficiency during pregnancy is associated with infertility and miscarriage in women. Numerous cell populations at the maternal-fetal interface are regulated by LIF/IL11 including the endometrial epithelium, decidualizing stroma, placental trophoblasts and leukocytes. This review focuses on the roles of LIF/IL11 during early pregnancy and highlights their potential as contraceptive targets and therapeutic agents for infertility.
AB - Blastocyst implantation into a receptive endometrium is critical to the establishment of pregnancy and is tightly regulated by factors within the blastocyst-endometrial micro-environment. Leukemia inhibitory factor (LIF) and interleukin-11 (IL11) have key roles during implantation. Female mice with a null mutation in the LIF or IL11RA gene are infertile due to a complete failure of implantation or a defective differentiation/decidualization response to the implanting blastocyst, respectively. LIF and IL11 deficiency during pregnancy is associated with infertility and miscarriage in women. Numerous cell populations at the maternal-fetal interface are regulated by LIF/IL11 including the endometrial epithelium, decidualizing stroma, placental trophoblasts and leukocytes. This review focuses on the roles of LIF/IL11 during early pregnancy and highlights their potential as contraceptive targets and therapeutic agents for infertility.
KW - Cytokine
KW - Fertility
KW - IL11
KW - Implantation
KW - LIF
UR - http://www.scopus.com/inward/record.url?scp=69349101567&partnerID=8YFLogxK
U2 - 10.1016/j.cytogfr.2009.07.001
DO - 10.1016/j.cytogfr.2009.07.001
M3 - Review Article
C2 - 19647472
AN - SCOPUS:69349101567
SN - 1359-6101
VL - 20
SP - 319
EP - 328
JO - Cytokine and Growth Factor Reviews
JF - Cytokine and Growth Factor Reviews
IS - 4
ER -