TY - JOUR
T1 - Leukaemic subtype of marginal zone lymphoma
T2 - A presentation of three cases and literature review
AU - Tam, Constantine S.
AU - Prince, H. Miles
AU - Westerman, David
AU - Seymour, John F.
AU - Juneja, Surender
PY - 2004/4
Y1 - 2004/4
N2 - The recent World Health Organization (WHO) classification recognizes three subtypes of marginal zone lymphoma (MZL): extranodal MZL of mucosa-associated lymphoid tissue (MALT), splenic MZL and nodal MZL. As a group, MZL share morphological and immunophenotypic features similar to that of the marginal zone B-cell in secondary B-follicles, the postulated common cell of origin. There is, however, increasing information about molecular heterogeneity between the types of MZL, suggesting different aetiology and highlighting our current incomplete understanding of this evolving entity. We describe the presentation and clinical course of three patients with MZL who do not fit the currently recognized WHO categories, and best fit the putative category of MZL, leukaemic subtype. We review the current literature on this newly described entity, highlighting the importance of its recognition.
AB - The recent World Health Organization (WHO) classification recognizes three subtypes of marginal zone lymphoma (MZL): extranodal MZL of mucosa-associated lymphoid tissue (MALT), splenic MZL and nodal MZL. As a group, MZL share morphological and immunophenotypic features similar to that of the marginal zone B-cell in secondary B-follicles, the postulated common cell of origin. There is, however, increasing information about molecular heterogeneity between the types of MZL, suggesting different aetiology and highlighting our current incomplete understanding of this evolving entity. We describe the presentation and clinical course of three patients with MZL who do not fit the currently recognized WHO categories, and best fit the putative category of MZL, leukaemic subtype. We review the current literature on this newly described entity, highlighting the importance of its recognition.
KW - Clinical presentation
KW - Differential diagnosis of LPD
KW - Leukemic subtype
KW - Marginal zone lymphoma
UR - http://www.scopus.com/inward/record.url?scp=1342344866&partnerID=8YFLogxK
U2 - 10.1080/10428190310001615657
DO - 10.1080/10428190310001615657
M3 - Article
C2 - 15160943
AN - SCOPUS:1342344866
SN - 1042-8194
VL - 45
SP - 705
EP - 710
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
IS - 4
ER -
